Literature DB >> 16986928

Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.

Till Opatz1, Dorota Ferenc.   

Abstract

Alpha-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically active compounds.

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Year:  2006        PMID: 16986928     DOI: 10.1021/ol061617+

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Design and synthesis of a novel tyrosine kinase inhibitor template.

Authors:  P Jake Slavish; Qin Jiang; Xiaoli Cui; Stephan W Morris; Thomas R Webb
Journal:  Bioorg Med Chem       Date:  2009-03-27       Impact factor: 3.641

2.  Synthesis of highly enantioenriched 3,4-dihydroquinolin-2-ones by 6-exo-trig radical cyclizations of axially chiral alpha-halo-ortho-alkenyl anilides.

Authors:  David B Guthrie; Steven J Geib; Dennis P Curran
Journal:  J Am Chem Soc       Date:  2009-10-28       Impact factor: 15.419

  2 in total

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