| Literature DB >> 16986927 |
Guido Christoph1, Christian Stratmann, Iain Coldham, Dieter Hoppe.
Abstract
We report a method for the synthesis of chiral pyrrolidines using tin-lithium exchange and cyclization reactions. The precursors are formed readily from simple starting materials and undergo tin-lithium exchange by treatment with n-butyllithium. Subsequent intramolecular carbolithiation is stereoselective to give highly enantiomerically enriched pyrrolidines in excellent yields.Entities:
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Year: 2006 PMID： 16986927 DOI： 10.1021/ol061615p
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005