Early Response Time in Sexual Activity and Mood Following Testosterone Gel Replacement in Hypogonadal Males from the Testim(R) START Study.

Sexual activity, sexual desire, and mood decrease in men with low testosterone levels. The Testim(R) Study of Testosterone Androgen Response Time (START) explored the time to response in sexual activity, desire, and mood following testosterone replacement therapy with Testim for 30 days in 638 hypogonadal men. Response in sexual activity, desire, and mood all improved relative to baseline within the first week of Testim therapy. Patients reached a maximal response by the end of 2 weeks of therapy and maintained the response through 4 weeks of therapy. Frequency of intercourse showed a significant increase after 2 weeks of Testim therapy. Both measures of positive mood and negative mood improved significantly, beginning with the first week of therapy and reaching and maintaining a maximal response at the second week.