Literature DB >> 1698580

Epitope mapping of an HLA-B27 monoclonal antibody that also reacts with a 35-kD bacterial outer-membrane protein.

A Toubert1, M Hamachi, C Raffoux, M S Park, D T Yu.   

Abstract

Ye-3 is an HLA-B27-specific murine monoclonal antibody recognizing the heat-modifiable protein of Enterobacteriaceae. Here we used recombinant hybrid molecules between the HLA-B7 and HLA-B27 antigens to delineate the epitope recognized by Ye-3. Results of these experiments indicated that the segment of HLA-B*2705 spanning residues 77-81 was critical to the reactive epitope. It is known to be a major serological and functional recognition site of HLA-B*2705 and our data give support for its involvement also in the serological cross-reactivity with bacterial antigens.

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Year:  1990        PMID： 1698580      PMCID： PMC1535162          DOI： 10.1111/j.1365-2249.1990.tb05397.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  24 in total

1.  Distribution of HLA-B27 subtypes in patients with ankylosing spondylitis: the disease is associated with a common determinant of the various B27 molecules.

Authors:  B S Breur-Vriesendorp; A J Dekker-Saeys; P Ivanyi
Journal:  Ann Rheum Dis       Date:  1987-05       Impact factor: 19.103

2.  A Yersinia pseudotuberculosis protein which cross-reacts with HLA-B27.

Authors:  J H Chen; D H Kono; Z Yong; M S Park; M M Oldstone; D T Yu
Journal:  J Immunol       Date:  1987-11-01       Impact factor: 5.422

3.  Epitope mapping of HLA-B27 and HLA-B7 antigens by using intradomain recombinants.

Authors:  A Toubert; C Raffoux; J Boretto; J Sire; R Sodoyer; S R Thurau; B Amor; J Colombani; F A Lemonnier; B R Jordan
Journal:  J Immunol       Date:  1988-10-01       Impact factor: 5.422

Review 4.  Significance of the HLA molecular structure to transplantation.

Authors:  M S Park; P I Terasaki; A Barbetti; H Han; J M Cecka
Journal:  Clin Transpl       Date:  1988

5.  The bacterial outer membrane protein that reacts with anti-HLA-B27 antibodies is the OmpA protein.

Authors:  J J Zhang; M Hamachi; T Hamachi; Y P Zhao; D T Yu
Journal:  J Immunol       Date:  1989-11-01       Impact factor: 5.422

6.  Delineation of determinants on HLA-B7 and HLA-B27 that are necessary for cytolytic T cell recognition by using inter- and intra-domain recombinants.

Authors:  F Healy; A Toubert; E Gomard; B R Jordan; J P Levy
Journal:  J Immunol       Date:  1989-10-01       Impact factor: 5.422

7.  Cross-reactive epitope with Klebsiella pneumoniae nitrogenase in articular tissue of HLA-B27+ patients with ankylosing spondylitis.

Authors:  G Husby; N Tsuchiya; P L Schwimmbeck; A Keat; J A Pahle; M B Oldstone; R C Williams
Journal:  Arthritis Rheum       Date:  1989-04

8.  Identification of a 2-Md plasmid from Shigella flexneri associated with reactive arthritis.

Authors:  H Stieglitz; S Fosmire; P Lipsky
Journal:  Arthritis Rheum       Date:  1989-08

9.  In vitro mutagenesis of HLA-B27. Substitution of an unpaired cysteine residue in the alpha 1 domain causes loss of antibody-defined epitopes.

Authors:  J D Taurog; F A el-Zaatari
Journal:  J Clin Invest       Date:  1988-09       Impact factor: 14.808

10.  Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome. Molecular mimicry with Klebsiella pneumoniae as potential mechanism of autoimmune disease.

Authors:  P L Schwimmbeck; D T Yu; M B Oldstone
Journal:  J Exp Med       Date:  1987-07-01       Impact factor: 14.307
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  3 in total

1.  How does HLA-B27 confer susceptibility to inflammatory arthritis?

Authors:  J S Gaston
Journal:  Clin Exp Immunol       Date:  1990-10       Impact factor: 4.330

2.  HLA-B27 determination using serological methods. A comparison of enzyme immunoassay and a microlymphocytotoxic test with flow cytometry and a molecular biological assay.

Authors:  A Dunky; J Neumüller; C Hübner; G F Fischer; P M Bayer; E Wagner; D W Schwartz; W R Mayr
Journal:  Rheumatol Int       Date:  1996       Impact factor: 2.631

3.  Failure of the serological determination of HLA-B27 due to antigen masking in patients with ankylosing spondylitis.

Authors:  J Neumüller; M Fischer; R Eberl
Journal:  Rheumatol Int       Date:  1993       Impact factor: 2.631
  3 in total

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