Literature DB >> 1698577

Simultaneous determination of acidic 3,4-dihydroxyphenylalanine metabolites and 5-hydroxyindole-3-acetic acid in urine by high-performance liquid chromatography.

A E Stroomer1, H Overmars, N G Abeling, A H van Gennip.   

Abstract

We describe a simple and rapid quantitative method for the simultaneous determination of 3,4-dihydroxyphenylalanine acid metabolites and 5-hydroxyindole-3-acetic acid. After solvent extraction from acidified urine, the acids are analyzed by reversed-phase high-performance liquid chromatography. For detection and quantification, we used a fluorescence detector in combination with an amperometric detector to obtain a high degree of specificity. Sample preparation and chromatographic analysis can be completed within an hour. Results by the method correlate well with those by a previously used gas-chromatographic method, but the new method is faster and avoids the need for derivatization.

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Year:  1990        PMID： 1698577

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  6 in total

1.  Aromatic L-amino acid decarboxylase deficiency: a new case with a mild clinical presentation and unexpected laboratory findings.

Authors:  N G Abeling; A H van Gennip; P G Barth; A van Cruchten; M Westra; F A Wijburg
Journal:  J Inherit Metab Dis       Date:  1998-06       Impact factor: 4.982

2.  Biogenic amine metabolite patterns in the urine of monoamine oxidase A-deficient patients. A possible tool for diagnosis.

Authors:  N G Abeling; A H van Gennip; H Overmars; B A van Oost; H G Brunner
Journal:  J Inherit Metab Dis       Date:  1994       Impact factor: 4.982

3.  Tyrosine hydroxylase deficiency unresponsive to L-dopa treatment with unusual clinical and biochemical presentation.

Authors:  P DE Lonlay; M C Nassogne; A H van Gennip; A C van Cruchten; T Billatte de Villemeur; M Cretz; C Stoll; J M Launay; G C Steenberger-Spante; L P van den Heuvel; R A Wevers; J M Saudubray; N G Abeling
Journal:  J Inherit Metab Dis       Date:  2000-12       Impact factor: 4.982

4.  Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes.

Authors:  J W Lenders; G Eisenhofer; N G Abeling; W Berger; D L Murphy; C H Konings; L M Wagemakers; I J Kopin; F Karoum; A H van Gennip; H G Brunner
Journal:  J Clin Invest       Date:  1996-02-15       Impact factor: 14.808

5.  X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.

Authors:  H G Brunner; M R Nelen; P van Zandvoort; N G Abeling; A H van Gennip; E C Wolters; M A Kuiper; H H Ropers; B A van Oost
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025

6.  Role of natriuretic peptides in the diagnosis and treatment of patients with carcinoid heart disease.

Authors:  J M Zuetenhorst; C M Korse; J M G Bonfrer; R H Bakker; B G Taal
Journal:  Br J Cancer       Date:  2004-06-01       Impact factor: 7.640
  6 in total

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