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Literature DB >> 16985657

Botulinum toxin: poisoning the spastic bladder and urethra.

Christopher P Smith, George T Somogyi, Michael B Chancellor.

Abstract

Botulinum toxin has proven to be a safe and effective therapy for a variety of somatic and autonomic motor disorders. Urologists are now finding clinical success with urethral and bladder injection of this fascinating toxin for detrusor sphincter dyssynergia, conditions of pelvic floor spasticity, and overactive bladder. One cannot deny the ingenuity of man in transforming the lethal toxin of Clostridium botulinum into a modern day therapeutic medicine.

Entities: Disease Species

Year: 2002 PMID： 16985657 PMCID： PMC1475967

Source DB: PubMed Journal: Rev Urol ISSN： 1523-6161

35 in total

1. Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients.

Authors: D D Dykstra; A A Sidi; A B Scott; J M Pagel; G D Goldish
Journal: J Urol Date: 1988-05 Impact factor: 7.450

2. A method for the measurement of [3H]-glutamate release from cultured dorsal root ganglion neurons.

Authors: J R Purkiss; M J Welch; S Doward; K A Foster; C P Quinn
Journal: Biochem Soc Trans Date: 1998-05 Impact factor: 5.407

3. The effects of purified botulinum neurotoxin type A on cholinergic, adrenergic and non-adrenergic, atropine-resistant autonomic neuromuscular transmission.

Authors: I MacKenzie; G Burnstock; J O Dolly
Journal: Neuroscience Date: 1982-04 Impact factor: 3.590

Review 4. Botulinum toxin therapy, immunologic resistance, and problems with available materials.

Authors: G Borodic; E Johnson; M Goodnough; E Schantz
Journal: Neurology Date: 1996-01 Impact factor: 9.910

5. Botulinum toxin treatment of cranial-cervical dystonia, spasmodic dysphonia, other focal dystonias and hemifacial spasm.

Authors: J Jankovic; K Schwartz; D T Donovan
Journal: J Neurol Neurosurg Psychiatry Date: 1990-08 Impact factor: 10.154

Botulinum toxin: poisoning the spastic bladder and urethra.

1. Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients.

2. A method for the measurement of [3H]-glutamate release from cultured dorsal root ganglion neurons.

3. The effects of purified botulinum neurotoxin type A on cholinergic, adrenergic and non-adrenergic, atropine-resistant autonomic neuromuscular transmission.

Review 4. Botulinum toxin therapy, immunologic resistance, and problems with available materials.

5. Botulinum toxin treatment of cranial-cervical dystonia, spasmodic dysphonia, other focal dystonias and hemifacial spasm.

6. Botulinum A toxin for the treatment of spasmodic torticollis: dysphagia and regional toxin spread.

7. The effect of botulinum toxin type A injection for intrinsic rhinitis.

8. Motor responses of the urinary bladder and skeletal muscle in botulinum intoxicated rats.

9. Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds.

10. Intrasphincteric botulinum toxin for the treatment of achalasia.

1. Differential diagnosis and treatment of impaired bladder emptying.

2. New frontiers in the treatment of overactive bladder and incontinence.

3. Urothelial mucosal signaling and the overactive bladder-ICI-RS 2013.