AIM: To evaluate the association of serum corticotropin-releasing hormone (CRH) and tumor necrosis factor-alpha (TNF-alpha) in preterm labor. METHODS: Forty-nine primigravidas with a singleton viable pregnancy between 28 and 34 weeks of gestation were studied. They were divided into two groups. Group A consisted of 30 pregnant women (mean gestational age: 30.6 week) who presented with preterm labor and group B consisted of 19 pregnant women (mean gestational age: 29.8 week) with normal pregnancies. RESULTS: Women of group A had significantly higher serum CRH levels compared to those of group B (P < 0.01). Similarly, serum TNF-alpha levels were significantly higher in women of group A when compared to women of group B (7.8 +/- 3.72 pg/mL and 5.1 +/- 3.72 pg/mL, respectively). Furthermore, a positive correlation was found between serum CRH and TNF-alpha levels in both groups, which was stronger in women of group A. CONCLUSIONS: Our findings suggest that the increased levels of TNF-alpha and CRH found in pregnant women presenting with preterm labor may be involved in the pathophysiological mechanism of the latter. Furthermore, a positive interaction may exist between TNF-alpha and placental CRH, which may lead to enhanced production of the second and, therefore, facilitate the onset of labor.
AIM: To evaluate the association of serum corticotropin-releasing hormone (CRH) and tumor necrosis factor-alpha (TNF-alpha) in preterm labor. METHODS: Forty-nine primigravidas with a singleton viable pregnancy between 28 and 34 weeks of gestation were studied. They were divided into two groups. Group A consisted of 30 pregnant women (mean gestational age: 30.6 week) who presented with preterm labor and group B consisted of 19 pregnant women (mean gestational age: 29.8 week) with normal pregnancies. RESULTS:Women of group A had significantly higher serum CRH levels compared to those of group B (P < 0.01). Similarly, serum TNF-alpha levels were significantly higher in women of group A when compared to women of group B (7.8 +/- 3.72 pg/mL and 5.1 +/- 3.72 pg/mL, respectively). Furthermore, a positive correlation was found between serum CRH and TNF-alpha levels in both groups, which was stronger in women of group A. CONCLUSIONS: Our findings suggest that the increased levels of TNF-alpha and CRH found in pregnant women presenting with preterm labor may be involved in the pathophysiological mechanism of the latter. Furthermore, a positive interaction may exist between TNF-alpha and placental CRH, which may lead to enhanced production of the second and, therefore, facilitate the onset of labor.
Authors: B D Pearce; J Grove; E A Bonney; N Bliwise; D J Dudley; D E Schendel; P Thorsen Journal: Gynecol Obstet Invest Date: 2010-02-17 Impact factor: 2.031
Authors: Jeremy L Neal; Jane M Lamp; Nancy K Lowe; Shannon L Gillespie; Loraine T Sinnott; Donna O McCarthy Journal: Am J Obstet Gynecol Date: 2014-07-31 Impact factor: 8.661
Authors: Laura L Jelliffe-Pawlowski; Kelli K Ryckman; Bruce Bedell; Hugh M O'Brodovich; Jeffrey B Gould; Dierdre J Lyell; Kristi S Borowski; Gary M Shaw; Jeffrey C Murray; David K Stevenson Journal: Am J Obstet Gynecol Date: 2014-05-13 Impact factor: 8.661