BACKGROUND: A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method to identify such occult change is needed. METHODS: Patients in the Oral Dysplasia Clinics at British Columbia are currently being examined with a simple hand-held device that permits the direct visualization of alterations to autofluorescence in the oral cavity. Tissue showing loss of autofluorescence is biopsied. RESULTS: We present 3 representative cases in which occult lesions were identified with fluorescence visualization during longitudinal follow-up, resulting in the diagnosis of a primary dysplasia in case 1, a second primary cancer in case 2, and cancer recurrence in case 3. CONCLUSIONS: This is the first report of the diagnosis of occult oral disease using a simple noninvasive device. These early examples indicate the potential value of this technology to guide the management of patients with oral lesions, facilitating the detection of high-risk changes not apparent with white-light visualization.
BACKGROUND: A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method to identify such occult change is needed. METHODS:Patients in the Oral Dysplasia Clinics at British Columbia are currently being examined with a simple hand-held device that permits the direct visualization of alterations to autofluorescence in the oral cavity. Tissue showing loss of autofluorescence is biopsied. RESULTS: We present 3 representative cases in which occult lesions were identified with fluorescence visualization during longitudinal follow-up, resulting in the diagnosis of a primary dysplasia in case 1, a second primary cancer in case 2, and cancer recurrence in case 3. CONCLUSIONS: This is the first report of the diagnosis of occult oral disease using a simple noninvasive device. These early examples indicate the potential value of this technology to guide the management of patients with oral lesions, facilitating the detection of high-risk changes not apparent with white-light visualization.
Authors: Gregory A Grillone; Zimmern Wang; Gintas P Krisciunas; Angela C Tsai; Vishnu R Kannabiran; Robert W Pistey; Qing Zhao; Eladio Rodriguez-Diaz; Ousama M A'Amar; Irving J Bigio Journal: Laryngoscope Date: 2017-07-28 Impact factor: 3.325
Authors: Denise M Laronde; P M Williams; T G Hislop; Catherine Poh; Samson Ng; Lewei Zhang; Miriam P Rosin Journal: Community Dent Oral Epidemiol Date: 2014-01-25 Impact factor: 3.383