Literature DB >> 16983598

The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis.

Cheng Xiao1, Cheng Lu, Linhua Zhao, Zhenli Liu, Wandong Zhang, Yinghui He, Shilin Chen, Johnny Cheuk-on Tang, Albert Sun-chi Chan, Aiping Lu.   

Abstract

For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-beta in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-beta level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.

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Year:  2006        PMID： 16983598     DOI： 10.1055/s-2006-947240

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  9 in total

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  9 in total

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