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Literature DB >> 16983515

Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer.

Sergei Kusmartsev¹, Dmitry I Gabrilovich.

Abstract

It is well established that cancers affect differentiation of dendritic cells and promote systemic expansion of immune suppressive immature myeloid cells. This phenomenon may represent a mechanism of tumor escape from immune attack and could have significant impact on tumor progression. In this review we discuss the role of different tumor-derived factors, which were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2006 PMID： 16983515 PMCID： PMC1693571 DOI： 10.1007/s10555-006-9002-6

Source DB: PubMed Journal: Cancer Metastasis Rev ISSN： 0167-7659 Impact factor: 9.264

68 in total

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Journal: Int Immunol Date: 1994-08 Impact factor: 4.823

65 in total

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10. Tumor microenvironment and myeloid-derived suppressor cells.

Authors: Viktor Umansky; Alexandra Sevko
Journal: Cancer Microenviron Date: 2012-12-16