Literature DB >> 16983503

The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats.

Cengiz Ara1, Mukaddes Esrefoglu, Alattin Polat, Burak Isik, Murat Aladag, Mehmet Gul, Selma Ay, M Sait Tekerleklioglu, Sezai Yilmaz.   

Abstract

We investigated the effect of caffeic acid phenethyl ester in rat ileum injury induced by chronic biliary obstruction. Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, common bile duct ligation (n = 7); and Group 3, common bile duct ligation plus caffeic acid phenethyl ester (n = 7). In the caffeic acid phenethyl ester-treated rats, ileum tissue levels of malondialdehyde and myeloperoxidase were significantly lower than those of the bile duct-ligated rats (P < 0.001). The levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-1alpha in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). The present study demonstrates that intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative stress. This effect may be useful in the preservation of intestinal damage in cholestasis.

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Year:  2006        PMID： 16983503     DOI： 10.1007/s10620-006-9130-4

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  39 in total

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Journal:  J Hepatol       Date:  1997-06       Impact factor: 25.083

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Journal:  Eur Surg Res       Date:  1997       Impact factor: 1.745

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Authors:  Pierpaolo Sileri; Sergio Morini; Giuseppe S Sica; Stefano Schena; Cristiana Rastellini; Achille L Gaspari; Enrico Benedetti; Luca Cicalese
Journal:  Dig Dis Sci       Date:  2002-04       Impact factor: 3.199

7.  Caffeic acid phenethyl ester to inhibit posterior capsule opacification in rabbits.

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Journal:  J Cataract Refract Surg       Date:  1997-12       Impact factor: 3.351

8.  Allopurinol reduces bacterial translocation, intestinal mucosal lipid peroxidation, and neutrophil-derived myeloperoxidase activity in chronic portal hypertensive and common bile duct-ligated growing rats.

Authors:  G Schimpl; P Pesendorfer; G Steinwender; G Feierl; M Ratschek; M E Höllwarth
Journal:  Pediatr Res       Date:  1996-09       Impact factor: 3.756

9.  Increased concentrations of tumour necrosis factor (TNF) and soluble TNF receptors in biliary obstruction in mice; soluble TNF receptors as prognostic factors for mortality.

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Journal:  Gut       Date:  1996-03       Impact factor: 23.059

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  4 in total

1.  The efficiency of CAPE on retardation of hepatic fibrosis in biliary obstructed rats.

Authors:  Ahmet Tomur; Mehmet Kanter; Ahmet Gurel; Mustafa Erboga
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2.  Protective effects of caffeic acid phenethyl ester (CAPE) on intestinal damage in necrotizing enterocolitis.

Authors:  Cuneyt Tayman; Alparslan Tonbul; Aydın Kosus; Ibrahim Murat Hirfanoglu; Hacer Haltas; Sema Uysal; Mustafa Mansur Tatli; Fatih Andiran
Journal:  Pediatr Surg Int       Date:  2011-06-28       Impact factor: 1.827

3.  Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice.

Authors:  Mehmet Zafer Sabuncuoglu; Kemal Kismet; Sibel Serin Kilicoglu; Bulent Kilicoglu; Serap Erel; Sabahattin Muratoglu; Asli Elif Sunay; Esra Erdemli; Mehmet Ali Akkus
Journal:  World J Gastroenterol       Date:  2007-10-21       Impact factor: 5.742

4.  Oral administration of thiol-reducing agents mitigates gut barrier disintegrity and bacterial lipopolysaccharide translocation in a rat model of biliary obstruction.

Authors:  Mohammad Mehdi Ommati; Omid Farshad; Hossein Niknahad; Khadijeh Mousavi; Marjan Moein; Negar Azarpira; Hamidreza Mohammadi; Akram Jamshidzadeh; Reza Heidari
Journal:  Curr Res Pharmacol Drug Discov       Date:  2020-06-16
  4 in total

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