Literature DB >> 16982833

Alleles 308A and 238A in the tumor necrosis factor alpha gene promoter do not increase the risk of severe malaria in children with Plasmodium falciparum infection in Mali.

Sandrine Cabantous1, Ogobara Doumbo, Stéphane Ranque, Belco Poudiougou, Abdoulaye Traore, Xunya Hou, Marouf M Keita, Mahamadou B Cisse, Alain J Dessein, Sandrine Marquet.   

Abstract

The hypothesis that tumor necrosis factor (TNF) aggravates malaria in children is supported by observations that TNF polymorphisms and high TNF levels have been associated with cerebral malaria. Nevertheless, severe malaria was not associated with polymorphisms located at positions -308A and -238A in the TNF alpha gene promoter or with a high TNF level in plasma in children from Bamako, Mali.

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Year:  2006        PMID： 16982833      PMCID： PMC1698072          DOI： 10.1128/IAI.01581-05

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

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  8 in total

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