Literature DB >> 16982823

Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans.

Shuichi Nishikubo1, Masaru Ohara, Masae Ikura, Katsuo Katayanagi, Tamaki Fujiwara, Hitoshi Komatsuzawa, Hidemi Kurihara, Motoyuki Sugai.   

Abstract

Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers ranging from 10(2) to 10(8) U/mg. Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating the chromatin-degrading activity of CdtB.

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Year:  2006        PMID： 16982823      PMCID： PMC1698065          DOI： 10.1128/IAI.02063-05

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Is CdtB a nuclease or a phosphatase?

Authors:  M Dlakic
Journal:  Science       Date:  2001-01-26       Impact factor: 47.728

2.  Prevalence of cytolethal distending toxin production in periodontopathogenic bacteria.

Authors:  Ryousuke Yamano; Masaru Ohara; Shuichi Nishikubo; Tamaki Fujiwara; Toru Kawamoto; Yoko Ueno; Hitoshi Komatsuzawa; Katsuji Okuda; Hidemi Kurihara; Hidekazu Suginaka; Eric Oswald; Kazuo Tanne; Motoyuki Sugai
Journal:  J Clin Microbiol       Date:  2003-04       Impact factor: 5.948

3.  An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus.

Authors:  Shuichi Nishikubo; Masaru Ohara; Yoko Ueno; Masae Ikura; Hidemi Kurihara; Hitoshi Komatsuzawa; Eric Oswald; Motoyuki Sugai
Journal:  J Biol Chem       Date:  2003-08-28       Impact factor: 5.157

4.  CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activity.

Authors:  M Lara-Tejero; J E Galán
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

5.  DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest.

Authors:  C A Elwell; L A Dreyfus
Journal:  Mol Microbiol       Date:  2000-08       Impact factor: 3.501

6.  Biogenesis of the Actinobacillus actinomycetemcomitans cytolethal distending toxin holotoxin.

Authors:  Yoko Ueno; Masaru Ohara; Toru Kawamoto; Tamaki Fujiwara; Hitoshi Komatsuzawa; Eric Oswald; Motoyuki Sugai
Journal:  Infect Immun       Date:  2006-06       Impact factor: 3.441

7.  The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells.

Authors:  LiQi Li; Anatoly Sharipo; Esteban Chaves-Olarte; Maria G Masucci; Victor Levitsky; Monica Thelestam; Teresa Frisan
Journal:  Cell Microbiol       Date:  2002-02       Impact factor: 3.715

8.  Interactions of Campylobacter jejuni cytolethal distending toxin subunits CdtA and CdtC with HeLa cells.

Authors:  Robert B Lee; Duane C Hassane; Daniel L Cottle; Carol L Pickett
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

9.  Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells.

Authors:  Duane C Hassane; Robert B Lee; Carol L Pickett
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441

10.  Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines.

Authors:  Masaru Ohara; Tomonori Hayashi; Yoichiro Kusunoki; Mutsumi Miyauchi; Takashi Takata; Motoyuki Sugai
Journal:  Infect Immun       Date:  2004-02       Impact factor: 3.441
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  5 in total

1.  Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells.

Authors:  Masaru Ohara; Tomonori Hayashi; Yoichiro Kusunoki; Kei Nakachi; Tamaki Fujiwara; Hitoshi Komatsuzawa; Motoyuki Sugai
Journal:  Infect Immun       Date:  2008-07-21       Impact factor: 3.441

Review 2.  Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis.

Authors:  Matthew Silbergleit; Adrian A Vasquez; Carol J Miller; Jun Sun; Ikuko Kato
Journal:  Prog Mol Biol Transl Sci       Date:  2020-04-09       Impact factor: 3.622

Review 3.  Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages.

Authors:  Rasika N Jinadasa; Stephen E Bloom; Robert S Weiss; Gerald E Duhamel
Journal:  Microbiology (Reading)       Date:  2011-05-12       Impact factor: 2.777

4.  Breaking the Gingival Epithelial Barrier: Role of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin in Oral Infectious Disease.

Authors:  Joseph M DiRienzo
Journal:  Cells       Date:  2014-05-23       Impact factor: 6.600

Review 5.  Cytolethal Distending Toxin Subunit B: A Review of Structure-Function Relationship.

Authors:  Benoît J Pons; Julien Vignard; Gladys Mirey
Journal:  Toxins (Basel)       Date:  2019-10-12       Impact factor: 4.546
  5 in total

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