Literature DB >> 16982796

Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.

Yan Sergerie1, Guy Boivin.   

Abstract

Contributions of thymidine kinase (TK) mutations to acyclovir (ACV) resistance were evaluated in herpes simplex virus type 1 recombinant viruses generated using a set of overlapping cosmids and plasmids. Alterations in both conserved and nonconserved regions of the TK gene were shown to confer high levels of resistance to ACV.

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Year:  2006        PMID： 16982796      PMCID： PMC1635219          DOI： 10.1128/AAC.00889-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome.

Authors:  K S Erlich; J Mills; P Chatis; G J Mertz; D F Busch; S E Follansbee; R M Grant; C S Crumpacker
Journal:  N Engl J Med       Date:  1989-02-02       Impact factor: 91.245

2.  Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide.

Authors:  D Graham; B A Larder; M M Inglis
Journal:  J Gen Virol       Date:  1986-04       Impact factor: 3.891

3.  The herpes simplex virus DNA polymerase: analysis of the functional domains.

Authors:  C W Knopf; K Weisshart
Journal:  Biochim Biophys Acta       Date:  1988-12-20

4.  Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir.

Authors:  Tatsuo Suzutani; Ken Ishioka; Erik De Clercq; Kei Ishibashi; Hisatoshi Kaneko; Toshihiko Kira; Koh-Ichi Hashimoto; Masahiro Ogasawara; Katsuki Ohtani; Nobutaka Wakamiya; Masayuki Saijo
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

5.  Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients.

Authors:  F Morfin; G Souillet; K Bilger; T Ooka; M Aymard; D Thouvenot
Journal:  J Infect Dis       Date:  2000-06-19       Impact factor: 5.226

6.  Role of genotypic analysis of the thymidine kinase gene of herpes simplex virus for determination of neurovirulence and resistance to acyclovir.

Authors:  N Y Lee; Y Tang; M J Espy; C P Kolbert; P N Rys; P S Mitchell; S P Day; S L Henry; D H Persing; T F Smith
Journal:  J Clin Microbiol       Date:  1999-10       Impact factor: 5.948

7.  Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?

Authors:  S L Sacks; R J Wanklin; D E Reece; K A Hicks; K L Tyler; D M Coen
Journal:  Ann Intern Med       Date:  1989-12-01       Impact factor: 25.391

Review 8.  Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms.

Authors:  Christian Gilbert; Julie Bestman-Smith; Guy Boivin
Journal:  Drug Resist Updat       Date:  2002-04       Impact factor: 18.500

9.  Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids.

Authors:  Julie Bestman-Smith; Guy Boivin
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

10.  Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: effects on catalytic activity.

Authors:  Q Y Liu; W C Summers
Journal:  Virology       Date:  1988-04       Impact factor: 3.616
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  4 in total

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Authors:  Jocelyne Piret; Guy Boivin
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

2.  Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility.

Authors:  Jocelyne Piret; Nathalie Goyette; Brian E Eckenroth; Emilien Drouot; Matthias Götte; Guy Boivin
Journal:  J Virol       Date:  2015-02-11       Impact factor: 5.103

3.  Novel Method Based on Real-Time Cell Analysis for Drug Susceptibility Testing of Herpes Simplex Virus and Human Cytomegalovirus.

Authors:  Jocelyne Piret; Nathalie Goyette; Guy Boivin
Journal:  J Clin Microbiol       Date:  2016-06-01       Impact factor: 5.948

4.  In Vitro and In Silico Analysis of the Inhibitory Activity of EGCG-Stearate against Herpes Simplex Virus-2.

Authors:  James D Stamos; Lee H Lee; Calvin Taylor; Tony Elias; Sandra D Adams
Journal:  Microorganisms       Date:  2022-07-20
  4 in total

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