AIM: To investigate the kinetics of adipocytokine in Kawasaki disease (KD). METHODS: The plasma levels of adiponectin, IL-6 and TNF-alpha were measured in 20 patients with KD, 15 patients with acute febrile diseases (disease control, DC) and 15 healthy children (HC). RESULTS: Plasma adiponectin levels in patients with acute KD were significantly lower (p < 0.01) than those with convalescent KD, DC and HC. The decreased levels of adiponectin negatively correlated with the increased levels of CRP and IL-6 in acute KD. CONCLUSION: Hypoadiponectinaemia was shown during the acute phase of KD vasculitis. The downregulation of adiponectin secreted from adipose tissue may be closely linked to upregulation of systemic pro-inflammatory markers in acute KD.
AIM: To investigate the kinetics of adipocytokine in Kawasaki disease (KD). METHODS: The plasma levels of adiponectin, IL-6 and TNF-alpha were measured in 20 patients with KD, 15 patients with acute febrile diseases (disease control, DC) and 15 healthy children (HC). RESULTS: Plasma adiponectin levels in patients with acute KD were significantly lower (p < 0.01) than those with convalescent KD, DC and HC. The decreased levels of adiponectin negatively correlated with the increased levels of CRP and IL-6 in acute KD. CONCLUSION: Hypoadiponectinaemia was shown during the acute phase of KD vasculitis. The downregulation of adiponectin secreted from adipose tissue may be closely linked to upregulation of systemic pro-inflammatory markers in acute KD.
Authors: A IJpma; L Te Riet; K M van de Luijtgaarden; P M van Heijningen; J Burger; D Majoor-Krakauer; E V Rouwet; J Essers; H J M Verhagen; I van der Pluijm Journal: J Cardiovasc Dev Dis Date: 2019-11-01