| Literature DB >> 16981134 |
Yi-Chen Chia1, Fang-Rong Chang, Chin-Chung Wu, Che-Ming Teng, Keh-Shaw Chen, Yang-Chang Wu.
Abstract
Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)- N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.Entities:
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Year: 2006 PMID： 16981134 DOI： 10.1055/s-2006-947196
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352