HYPOTHESIS: This study aims to investigate the therapeutic time window of methylprednisolone in acoustic injury. BACKGROUND: Although glucocorticoids have been widely used in the treatment of acoustic injury, the therapeutic time window of glucocorticoids in acoustic injury has never been examined. METHODS: Mice were exposed to 4-kHz pure tone of 128-dB sound pressure level for 4 hours. Auditory brainstem response was examined before, immediately after, and 2 weeks after acoustic overexposure. RESULTS: Methylprednisolone significantly improved the auditory brainstem response threshold shifts 2 weeks after acoustic overexposure when it was administered before or immediately after acoustic overexposure, but not when administered 3 hours after acoustic overexposure. CONCLUSION: The present findings suggest that methylprednisolone possesses protective effects against acoustic injury of the cochlea with a short therapeutic time window.
HYPOTHESIS: This study aims to investigate the therapeutic time window of methylprednisolone in acoustic injury. BACKGROUND: Although glucocorticoids have been widely used in the treatment of acoustic injury, the therapeutic time window of glucocorticoids in acoustic injury has never been examined. METHODS:Mice were exposed to 4-kHz pure tone of 128-dB sound pressure level for 4 hours. Auditory brainstem response was examined before, immediately after, and 2 weeks after acoustic overexposure. RESULTS:Methylprednisolone significantly improved the auditory brainstem response threshold shifts 2 weeks after acoustic overexposure when it was administered before or immediately after acoustic overexposure, but not when administered 3 hours after acoustic overexposure. CONCLUSION: The present findings suggest that methylprednisolone possesses protective effects against acoustic injury of the cochlea with a short therapeutic time window.
Authors: George Psillas; Pavlos Pavlidis; Ioannis Karvelis; George Kekes; Victor Vital; John Constantinidis Journal: Eur Arch Otorhinolaryngol Date: 2008-05-08 Impact factor: 2.503
Authors: Lukas D Landegger; Clemens Honeder; Chengjing Zhu; Hanna Schöpper; Elisabeth Engleder; Franz Gabor; Wolfgang Gstoettner; Christoph Arnoldner Journal: J Negat Results Biomed Date: 2016-05-11