Literature DB >> 16979930

Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx?

Rubén Cabanillas1, Juan P Rodrigo, Alfio Ferlito, Alessandra Rinaldo, Manuel F Fresno, Carolina Aguilar, Marta E Alvarez, Carlos Suárez.   

Abstract

The epidemiological link between human papillomavirus (HPV) DNA and basaloid squamous cell carcinoma (BSCC) of the pharynx was studied. The expression of p53 protein was evaluated by immunohistochemical analysis. The presence of HPV DNA was evaluated by polymerase chain reaction amplification and "in situ" hybridization. The tobacco and alcohol consumption and the clinical outcomes of nine patients with BSCC of the pharynx are compared with site and stage matched 109 conventional squamous cell carcinoma (SCC) patients. The BSCC specimens were analyzed for the presence of HPV DNA and p53 expression. We did not find any significant differences in tobacco and alcohol consumption between patients with BSCC and patients with SCC. No HPV DNA was detected in BSCC, and p53 overexpression was found in five (55%) of the cases. Our results do not support an etiological link between HPV DNA and BSCC.

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Year:  2006        PMID： 16979930     DOI： 10.1016/j.oraloncology.2006.04.014

Source DB:  PubMed          Journal:  Oral Oncol        ISSN： 1368-8375            Impact factor:   5.337


  9 in total

1.  Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma.

Authors:  Rebecca D Chernock; James S Lewis; Qin Zhang; Samir K El-Mofty
Journal:  Hum Pathol       Date:  2010-03-17       Impact factor: 3.466

Review 2.  How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

Authors:  Fernando López; Michelle D Williams; Antonio Cardesa; Jennifer L Hunt; Primož Strojan; Alessandra Rinaldo; Iain J Nixon; Juan P Rodrigo; Nabil F Saba; William M Mendenhall; Miquel Quer; Carlos Suárez; Alfio Ferlito
Journal:  Eur Arch Otorhinolaryngol       Date:  2017-03-31       Impact factor: 2.503

3.  Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases.

Authors:  Ryan Winters; Shelly Naud; Mark F Evans; Winifred Trotman; Peter Kasznica; Abdelmonem Elhosseiny
Journal:  Head Neck Pathol       Date:  2008-10-19

4.  Histologic identification of human papillomavirus (HPV)-related squamous cell carcinoma in cervical lymph nodes: a reliable predictor of the site of an occult head and neck primary carcinoma.

Authors:  Samir K El-Mofty; Megan Q Zhang; Rosa M Davila
Journal:  Head Neck Pathol       Date:  2008-06-24

Review 5.  Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature.

Authors:  Cosme Ereño; Ayman Gaafar; Maddi Garmendia; Carmen Etxezarraga; Francisco J Bilbao; José I López
Journal:  Head Neck Pathol       Date:  2008-03-21

6.  Basaloid Squamous Cell Carcinoma on the Skin of the Hand.

Authors:  Tae Hoon Kim; Jongho Lee; Iehyon Park; Ji Ung Park; Sung Tack Kwon
Journal:  Arch Plast Surg       Date:  2015-11-16

7.  From laryngeal epithelial precursor lesions to squamous carcinoma of the larynx: the role of cell cycle proteins and β-catenin.

Authors:  Fernando López; César Alvarez-Marcos; Marta Alonso-Guervós; Francisco Domínguez; Carlos Suárez; Mario A Hermsen; José L Llorente
Journal:  Eur Arch Otorhinolaryngol       Date:  2013-04-07       Impact factor: 2.503

8.  Alterations of p14 ARF , p15 INK4b , and p16 INK4a Genes in Primary Laryngeal Squamous Cell Carcinoma.

Authors:  Fernando López; Teresa Sampedro; José L Llorente; Mario Hermsen; César Álvarez-Marcos
Journal:  Pathol Oncol Res       Date:  2016-07-04       Impact factor: 3.201

9.  Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx.

Authors:  Filippo Ricciardiello; Michele Caraglia; Brigida Iorio; Teresa Abate; Mariarosaria Boccellino; Giuseppe Colella; Flavia Oliva; Pierpaolo Ferrise; Silvia Zappavigna; Mario Faenza; Giuseppe A Ferraro; Giulio Sequino; Giovanni Francesco Nicoletti; Massimo Mesolella
Journal:  Oncotarget       Date:  2017-09-28
  9 in total

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