Literature DB >> 16978837

Kinetic modeling of PET-FDG in the brain without blood sampling.

M'hamed Bentourkia1.   

Abstract

The aim in this work is to report a new method to calculate parametric images from a single scan acquisition with positron emission tomography (PET) and fluorodeoxyglucose (FDG) in the human brain without blood sampling. It is usually practical for research or clinical purposes to inject the patient in an isolated room and to start the PET acquisition only for some 10-20 min, about 30 min after FDG injection. In order to calculate the cerebral metabolic rates for glucose (CMRG), usually several blood samples are required. The proposed method considers the relation between the uptake of the tracer in the cerebellum as a reference tissue and the population based input curve. Similar results were obtained for CMRG values with the present method in comparison to the usual autoradiographic and the non-linear least squares fitting of regions of interest.

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Year:  2006        PMID： 16978837     DOI： 10.1016/j.compmedimag.2006.07.002

Source DB:  PubMed          Journal:  Comput Med Imaging Graph        ISSN： 0895-6111            Impact factor:   4.790


  7 in total

Review 1.  Determination of the Input Function at the Entry of the Tissue of Interest and Its Impact on PET Kinetic Modeling Parameters.

Authors:  M'hamed Bentourkia
Journal:  Mol Imaging Biol       Date:  2015-12       Impact factor: 3.488

2.  An input function estimation method for FDG-PET human brain studies.

Authors:  Hongbin Guo; Rosemary A Renaut; Kewei Chen
Journal:  Nucl Med Biol       Date:  2007-07       Impact factor: 2.408

Review 3.  Image-derived input function for brain PET studies: many challenges and few opportunities.

Authors:  Paolo Zanotti-Fregonara; Kewei Chen; Jeih-San Liow; Masahiro Fujita; Robert B Innis
Journal:  J Cereb Blood Flow Metab       Date:  2011-08-03       Impact factor: 6.200

4.  Simultaneous estimation of input functions: an empirical study.

Authors:  R Todd Ogden; Francesca Zanderigo; Stephen Choy; J John Mann; Ramin V Parsey
Journal:  J Cereb Blood Flow Metab       Date:  2009-12-09       Impact factor: 6.200

5.  Kinetic quantitation of cerebral PET-FDG studies without concurrent blood sampling: statistical recovery of the arterial input function.

Authors:  F O'Sullivan; J Kirrane; M Muzi; J N O'Sullivan; A M Spence; D A Mankoff; K A Krohn
Journal:  IEEE Trans Med Imaging       Date:  2009-08-25       Impact factor: 10.048

6.  Reliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio.

Authors:  Ralph Buchert; Meike Dirks; Christian Schütze; Florian Wilke; Martin Mamach; Ann-Katrin Wirries; Henning Pflugrad; Linda Hamann; Laura B N Langer; Christian Wetzel; Mario Lukacevic; Andras Polyak; Mariella Kessler; Carlotta Petrusch; Frank M Bengel; Lilli Geworski; Rainer Rupprecht; Karin Weissenborn; Tobias L Ross; Georg Berding
Journal:  Eur J Nucl Med Mol Imaging       Date:  2020-04-23       Impact factor: 9.236

7.  Population-based input function for TSPO quantification and kinetic modeling with [11C]-DPA-713.

Authors:  Mercy I Akerele; Sara A Zein; Sneha Pandya; Anastasia Nikolopoulou; Susan A Gauthier; Ashish Raj; Claire Henchcliffe; P David Mozley; Nicolas A Karakatsanis; Ajay Gupta; John Babich; Sadek A Nehmeh
Journal:  EJNMMI Phys       Date:  2021-04-29
  7 in total

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