Literature DB >> 1697754

Bidirectional regulation of cAMP generating system by dopamine-D1 and D2-receptors in the rat retina.

J Z Nowak1, B Sek, M Schorderet.   

Abstract

Accumulation or inhibition of cAMP formation in response to dopamine or dopamine related drugs in the absence or in the presence of forskolin and/or IBMX was investigated in isolated rat retina. While the existence of D1-receptors (positively coupled with adenylate cyclase) was confirmed, D2-receptors (negatively coupled to adenylate cyclase) were also revealed by using a selective D1-antagonist (SCH 23390), a D2-agonist (LY 171555) or two D2-antagonists (S-sulpiride, spiroperidol). These results indicate that rat retina may be used for the study of both types of dopamine-receptors.

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Year:  1990        PMID： 1697754     DOI： 10.1007/bf01245045

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  8 in total

1.  A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

Authors:  B L Brown; J D Albano; R P Ekins; A M Sgherzi
Journal:  Biochem J       Date:  1971-02       Impact factor: 3.857

Review 2.  Two dopamine receptors: biochemistry, physiology and pharmacology.

Authors:  J C Stoof; J W Kebabian
Journal:  Life Sci       Date:  1984-12-03       Impact factor: 5.037

3.  Dopaminergic regulation of cone retinomotor movement in isolated teleost retinas: I. Induction of cone contraction is mediated by D2 receptors.

Authors:  A Dearry; B Burnside
Journal:  J Neurochem       Date:  1986-04       Impact factor: 5.372

4.  Involvement of D1 and D2 Dopamine Receptors in the Control of Horizontal Cell Electrical Coupling in the Turtle Retina.

Authors:  M. Piccolino; G. Demontis; P. Witkovsky; E. Strettoi; G. C. Cappagli; M. L. Porceddu; M. G. De Montis; S. Pepitoni; G. Biggio; E. Meller; K. Bohmaker
Journal:  Eur J Neurosci       Date:  1989-05       Impact factor: 3.386

5.  Evidence for a D2 dopamine receptor in frog retina that decreases cyclic AMP accumulation and serotonin N-acetyltransferase activity.

Authors:  P M Iuvone
Journal:  Life Sci       Date:  1986-01-27       Impact factor: 5.037

6.  Pharmacological differences between the D-2 autoreceptor and the D-1 dopamine receptor in rabbit retina.

Authors:  M L Dubocovich; N Weiner
Journal:  J Pharmacol Exp Ther       Date:  1985-06       Impact factor: 4.030

7.  Light modulates dopamine-regulated Walsh inhibitor activity and dopamine-dependent cyclic AMP accumulation in the rabbit retina.

Authors:  J Z Nowak; J Zawilska; B Sek; M Schorderet
Journal:  Pol J Pharmacol Pharm       Date:  1990 Sep-Oct

8.  Pharmacological characterization of rat retinal dopamine receptors.

Authors:  Z X Qu; R Fertel; N H Neff; M Hadjiconstantinou
Journal:  J Pharmacol Exp Ther       Date:  1989-02       Impact factor: 4.030
  8 in total
  2 in total

Review 1.  Retinal dopamine D1 and D2 receptors: characterization by binding or pharmacological studies and physiological functions.

Authors:  M Schorderet; J Z Nowak
Journal:  Cell Mol Neurobiol       Date:  1990-09       Impact factor: 5.046

Review 2.  Phospholipase C-β1 Hypofunction in the Pathogenesis of Schizophrenia.

Authors:  Seong-Wook Kim; Taesup Cho; Sukchan Lee
Journal:  Front Psychiatry       Date:  2015-11-17       Impact factor: 4.157
  2 in total

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