| Literature DB >> 16973879 |
Manuel A Fernández1, Cecilia Albor, Mercedes Ingelmo-Torres, Susan J Nixon, Charles Ferguson, Teymuras Kurzchalia, Francesc Tebar, Carlos Enrich, Robert G Parton, Albert Pol.
Abstract
Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene-disrupted mice (cav1-/- mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy. Hepatocytes showed dramatically reduced lipid droplet accumulation and did not advance through the cell division cycle. Treatment of cav1-/- mice with glucose (which is a predominant energy substrate when compared to lipids) drastically increased survival and reestablished progression of the cell cycle. Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury.Entities:
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Year: 2006 PMID： 16973879 DOI： 10.1126/science.1130773
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728