| Literature DB >> 16973269 |
A Vania Apkarian1, Simona Lavarello, Anke Randolf, Hector H Berra, Dante R Chialvo, Hugo O Besedovsky, Adriana del Rey.
Abstract
We examined mRNA expression of the pro-inflammatory cytokine IL-1beta in the brainstem, thalamus, and prefrontal cortex in two rat models of neuropathic pain. Rats received a neuropathic injury: spared nerve injury (SNI) or chronic constriction injury (CCI), sham injury, or were minimally handled (control). Neuropathic pain-like behavior was monitored by tracking tactile thresholds. SNI-injured animals showed a robust decrease in tactile thresholds of the injured foot, while CCI-injured animals did not show tactile threshold changes. Ten or 24 days after nerve injury, IL-1beta gene expression in the brain was determined by RT-PCR. IL-1beta expression changes were observed mainly at 10 days after injury in the SNI animals, contralateral to the injury side, with increased expression in the brainstem and prefrontal cortex. The results indicate that neuro-immune activation in neuropathic pain conditions includes supraspinal brain regions, suggesting cytokine modulation of supraspinal circuitry of pain in neuropathic conditions.Entities:
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Year: 2006 PMID： 16973269 PMCID： PMC1851944 DOI： 10.1016/j.neulet.2006.08.034
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046