Literature DB >> 16973244

Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice.

Xian Lin1, Hoon Shim, Huaibin Cai.   

Abstract

Dysfunction of the ALS2 gene has been linked to one form of juvenile onset autosomal recessive amyotrophic lateral sclerosis (ALS). Previous in vitro studies suggest that over-expression of ALS2 protects cells from mutant Cu/Zn superoxide dismutase (SOD1)-induced cytotoxicity. To test whether ALS2 plays a protective role against mutant SOD1-mediated motor neuron degeneration in vivo, we examined the progression of motor neuron disease in SOD1(G93A) mice on an ALS2 null background. Our data suggest that deficiency in the ALS2 gene does not affect the pathogenesis of SOD1(G93A) mice.

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Year:  2006        PMID： 16973244      PMCID： PMC2423343          DOI： 10.1016/j.neurobiolaging.2006.07.014

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  9 in total

Review 1.  From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS.

Authors:  D W Cleveland; J D Rothstein
Journal:  Nat Rev Neurosci       Date:  2001-11       Impact factor: 34.870

2.  Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking.

Authors:  Shinji Hadano; Susanna C Benn; Shigeru Kakuta; Asako Otomo; Katsuko Sudo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Hikaru Mizumura; Jeremy M Shefner; Gregory A Cox; Yoichiro Iwakura; Robert H Brown; Joh-E Ikeda
Journal:  Hum Mol Genet       Date:  2005-12-01       Impact factor: 6.150

3.  The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.

Authors:  Y Yang; A Hentati; H X Deng; O Dabbagh; T Sasaki; M Hirano; W Y Hung; K Ouahchi; J Yan; A C Azim; N Cole; G Gascon; A Yagmour; M Ben-Hamida; M Pericak-Vance; F Hentati; T Siddique
Journal:  Nat Genet       Date:  2001-10       Impact factor: 38.330

4.  A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.

Authors:  S Hadano; C K Hand; H Osuga; Y Yanagisawa; A Otomo; R S Devon; N Miyamoto; J Showguchi-Miyata; Y Okada; R Singaraja; D A Figlewicz; T Kwiatkowski; B A Hosler; T Sagie; J Skaug; J Nasir; R H Brown; S W Scherer; G A Rouleau; M R Hayden; J E Ikeda
Journal:  Nat Genet       Date:  2001-10       Impact factor: 38.330

5.  A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death.

Authors:  Kohsuke Kanekura; Yuichi Hashimoto; Yoshiko Kita; Jumpei Sasabe; Sadakazu Aiso; Ikuo Nishimoto; Masaaki Matsuoka
Journal:  J Biol Chem       Date:  2004-12-03       Impact factor: 5.157

6.  Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress.

Authors:  Huaibin Cai; Xian Lin; Chengsong Xie; Fiona M Laird; Chen Lai; Hongjin Wen; Hsueh-Cheng Chiang; Hoon Shim; Mohamed H Farah; Ahmet Hoke; Donald L Price; Philip C Wong
Journal:  J Neurosci       Date:  2005-08-17       Impact factor: 6.167

7.  ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.

Authors:  Shinji Hadano; Asako Otomo; Kyoko Suzuki-Utsunomiya; Ryota Kunita; Yoshiko Yanagisawa; Junko Showguchi-Miyata; Hikaru Mizumura; Joh-E Ikeda
Journal:  FEBS Lett       Date:  2004-09-24       Impact factor: 4.124

8.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.

Authors:  M E Gurney; H Pu; A Y Chiu; M C Dal Canto; C Y Polchow; D D Alexander; J Caliendo; A Hentati; Y W Kwon; H X Deng
Journal:  Science       Date:  1994-06-17       Impact factor: 47.728

9.  A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice.

Authors:  Dairin Kieran; Majid Hafezparast; Stephanie Bohnert; James R T Dick; Joanne Martin; Giampietro Schiavo; Elizabeth M C Fisher; Linda Greensmith
Journal:  J Cell Biol       Date:  2005-05-23       Impact factor: 10.539
  9 in total
  5 in total

Review 1.  Transgenic animal models of neurodegeneration based on human genetic studies.

Authors:  Brandon K Harvey; Christopher T Richie; Barry J Hoffer; Mikko Airavaara
Journal:  J Neural Transm (Vienna)       Date:  2010-10-08       Impact factor: 3.575

Review 2.  Alsin and the molecular pathways of amyotrophic lateral sclerosis.

Authors:  Jayanth Chandran; Jinhui Ding; Huaibin Cai
Journal:  Mol Neurobiol       Date:  2007-07-10       Impact factor: 5.590

3.  Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.

Authors:  Shinji Hadano; Asako Otomo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Akira Akatsuka; Masato Koike; Masashi Aoki; Yasuo Uchiyama; Yasuto Itoyama; Joh-E Ikeda
Journal:  PLoS One       Date:  2010-03-22       Impact factor: 3.240

Review 4.  ALS2/alsin knockout mice and motor neuron diseases.

Authors:  Huaibin Cai; Hoon Shim; Chen Lai; Chengsong Xie; Xian Lin; Wan Jou Yang; Jayanth Chandran
Journal:  Neurodegener Dis       Date:  2008-08-20       Impact factor: 2.977

Review 5.  ALS2-Related Motor Neuron Diseases: From Symptoms to Molecules.

Authors:  Marcello Miceli; Cécile Exertier; Marco Cavaglià; Elena Gugole; Marta Boccardo; Rossana Rita Casaluci; Noemi Ceccarelli; Alessandra De Maio; Beatrice Vallone; Marco A Deriu
Journal:  Biology (Basel)       Date:  2022-01-05
  5 in total

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