OBJECTIVE: Epidemiological, clinical and histological data suggest intriguing similarities between preeclampsia and graft-host-rejection. Granulysin, a novel biomarker of overall cellular immunity, is secreted by natural killer cells and cytotoxic T lymphocytes, which are associated with graft-host-rejection. Plasma granulysin was elevated in Japanese preeclamptic women. DESIGN AND METHODS: 50 preeclampsia cases and 50 normotensive controls (USA) were studied. Plasma granulysin at delivery was determined using enzyme immunoassay. Logistic regression procedures were used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Granulysin were elevated in preeclampsia cases compared with controls (3.01+/-0.18 vs. 2.22+/-0.14 ng/mL, p<0.01). After adjusting for age, body-mass-index and race, women with higher granulysin concentrations (> or =1.89 ng/mL) experienced a 2.9-fold (95%CI 1.1-7.8) increased preeclampsia risk compared with women with lower granulysin (<1.89 ng/mL). CONCLUSIONS: These data offer further evidence of a predominant Th1 immune status associated with preeclampsia. Prospective studies are needed to determine whether granulysin is elevated early in pregnancy.
OBJECTIVE: Epidemiological, clinical and histological data suggest intriguing similarities between preeclampsia and graft-host-rejection. Granulysin, a novel biomarker of overall cellular immunity, is secreted by natural killer cells and cytotoxic T lymphocytes, which are associated with graft-host-rejection. Plasma granulysin was elevated in Japanese preeclamptic women. DESIGN AND METHODS: 50 preeclampsia cases and 50 normotensive controls (USA) were studied. Plasma granulysin at delivery was determined using enzyme immunoassay. Logistic regression procedures were used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS:Granulysin were elevated in preeclampsia cases compared with controls (3.01+/-0.18 vs. 2.22+/-0.14 ng/mL, p<0.01). After adjusting for age, body-mass-index and race, women with higher granulysin concentrations (> or =1.89 ng/mL) experienced a 2.9-fold (95%CI 1.1-7.8) increased preeclampsia risk compared with women with lower granulysin (<1.89 ng/mL). CONCLUSIONS: These data offer further evidence of a predominant Th1 immune status associated with preeclampsia. Prospective studies are needed to determine whether granulysin is elevated early in pregnancy.
Authors: M M Sarwal; A Jani; S Chang; P Huie; Z Wang; O Salvatierra; C Clayberger; R Sibley; A M Krensky; M Pavlakis Journal: Hum Immunol Date: 2001-01 Impact factor: 2.850
Authors: Cuilin Zhang; Michelle A Williams; Irena B King; Edward E Dashow; Tanya K Sorensen; Ihunnaya O Frederick; Mary Lou Thompson; David A Luthy Journal: Epidemiology Date: 2002-07 Impact factor: 4.822
Authors: Poonam Tewary; De Yang; Gonzalo de la Rosa; Yana Li; Michael W Finn; Alan M Krensky; Carol Clayberger; Joost J Oppenheim Journal: Blood Date: 2010-07-21 Impact factor: 22.113