BACKGROUND: The 19-item Acne-QoL is a validated psychometric instrument designed for use in clinical trials. OBJECTIVE: The purpose of this study was to develop a condensed version of the Acne-QoL as an alternative measure of psychosocial impact for use in routine clinical practice. METHODS: Four condensed versions of the Acne-QoL were evaluated by regression analysis in a subset of 434 patients. The version with four items most broadly representative of acne-specific quality of life combined with a high level of correlation to Acne-QoL total score was selected for further validation in two different patient samples. RESULTS: The patient ranked condensation, representing items from each domain of greatest patient-perceived importance and relevance was selected for further analysis (Acne-Q(4)). The Acne-Q(4) explained 98.5% of the variation in total score of Acne-QoL. Validation of the Acne-Q(4) in a follow-up group and an independent subset of patients resulted in Pearson correlation coefficients of 0.967 (p<0.001). Construct validity of the Acne-Q(4) was confirmed by demonstrating a similar relationship as the Acne-QoL to acne severity. LIMITATIONS: There is less breadth and detail of QoL information in the Acne-Q(4) than in the Acne-QoL. The analysis relied on a total score for Acne-QoL, which the original developers did not validate. CONCLUSIONS: The Acne-Q(4) is accurately reflective of the parent instrument and may facilitate the psychometric evaluation of the impact of facial acne on patients in routine clinical practice by its practicality.
BACKGROUND: The 19-item Acne-QoL is a validated psychometric instrument designed for use in clinical trials. OBJECTIVE: The purpose of this study was to develop a condensed version of the Acne-QoL as an alternative measure of psychosocial impact for use in routine clinical practice. METHODS: Four condensed versions of the Acne-QoL were evaluated by regression analysis in a subset of 434 patients. The version with four items most broadly representative of acne-specific quality of life combined with a high level of correlation to Acne-QoL total score was selected for further validation in two different patient samples. RESULTS: The patient ranked condensation, representing items from each domain of greatest patient-perceived importance and relevance was selected for further analysis (Acne-Q(4)). The Acne-Q(4) explained 98.5% of the variation in total score of Acne-QoL. Validation of the Acne-Q(4) in a follow-up group and an independent subset of patients resulted in Pearson correlation coefficients of 0.967 (p<0.001). Construct validity of the Acne-Q(4) was confirmed by demonstrating a similar relationship as the Acne-QoL to acne severity. LIMITATIONS: There is less breadth and detail of QoL information in the Acne-Q(4) than in the Acne-QoL. The analysis relied on a total score for Acne-QoL, which the original developers did not validate. CONCLUSIONS: The Acne-Q(4) is accurately reflective of the parent instrument and may facilitate the psychometric evaluation of the impact of facial acne on patients in routine clinical practice by its practicality.
Authors: J B Bjorner; M Aa Petersen; M Groenvold; N Aaronson; M Ahlner-Elmqvist; J I Arraras; A Brédart; P Fayers; M Jordhoy; M Sprangers; M Watson; T Young Journal: Qual Life Res Date: 2004-12 Impact factor: 4.147
Authors: S E Fehnel; L D McLeod; J Brandman; D I Arbit; C J McLaughlin-Miley; J H Coombs; A R Martin; C J Girman Journal: Qual Life Res Date: 2002-12 Impact factor: 4.147
Authors: C J Girman; S Hartmaier; D Thiboutot; J Johnson; B Barber; C DeMuro-Mercon; J Waldstreicher Journal: Qual Life Res Date: 1996-10 Impact factor: 4.147
Authors: Slavenka Jankovic; Jelica Vukicevic; Sanja Djordjevic; Janko Jankovic; Jelena Marinkovic; Mohammad K A Basra Journal: Qual Life Res Date: 2012-02-24 Impact factor: 4.147