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Literature DB >> 16971940

Tumour biology: Policing of oncogene activity by p53.

Alejo Efeyan¹, Isabel Garcia-Cao, Daniel Herranz, Susana Velasco-Miguel, Manuel Serrano.

Abstract

Entities: Gene

Mesh：

Substances：

Year: 2006 PMID： 16971940 DOI： 10.1038/443159a

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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44 in total

1. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.

Authors: Yong-Yu Liu; Gauri A Patwardhan; Kaustubh Bhinge; Vineet Gupta; Xin Gu; S Michal Jazwinski
Journal: Cancer Res Date: 2011-01-28 Impact factor: 12.701

2. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.

Authors: Lijian Shao; Yan Sun; Zhonghui Zhang; Wei Feng; Yongxing Gao; Zailong Cai; Zack Z Wang; A Thomas Look; Wen-Shu Wu
Journal: Blood Date: 2010-04-01 Impact factor: 22.113

3. The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development.

Authors: Cassandra J Adams; Jennifer S Yu; Jian-Hua Mao; Kuang-Yu Jen; Sylvain V Costes; Mark Wade; Jocelyn Shoemake; Olulanu H Aina; Reyno Del Rosario; Phuong Thuy Menchavez; Robert D Cardiff; Geoffrey M Wahl; Allan Balmain
Journal: Mol Carcinog Date: 2015-08-27 Impact factor: 4.784

Tumour biology: Policing of oncogene activity by p53.

1. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.

2. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.

3. The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development.

4. ATR signaling can drive cells into senescence in the absence of DNA breaks.

5. Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.

Review 6. p53--a Jack of all trades but master of none.

Review 7. Versatile functions of p53 protein in multicellular organisms.

8. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

Review 9. Drugging the p53 pathway: understanding the route to clinical efficacy.

10. A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres.