BACKGROUND: Genetic analysis of human longevity may be useful for the understanding of molecular mechanisms implicated in age-related diseases. The molecular genetics of human longevity is largely unexplored in Latin American populations and other developing countries. METHODS: To explore the possibility of an association of common polymorphisms in two candidate genes and longevity in Colombia, we analyzed two polymorphisms in apolipoprotein E (APOE) and angiotensin-converting enzyme (ACE) genes in a sample of 538 Colombian subjects (18-106 years), using previously validated PCR-based methodologies. RESULTS: We found a significant decrease in ACE DD genotype (24 vs. 16%) between young and old subject groups (mean age: 45 vs. 77 years) (p = 0.03). The ACE DD genotype and D allele decrease was significant only in women. There were no differences for APOE polymorphism between young and old subjects. CONCLUSIONS: Our results are compatible with the expected age-related decrease of ACE DD genotype. Future studies examining functional single nucleotide polymorphisms (SNPs) in the ACE gene and its correlation with serum ACE activity in the older subjects and their younger relatives in this sample are warranted.
BACKGROUND: Genetic analysis of human longevity may be useful for the understanding of molecular mechanisms implicated in age-related diseases. The molecular genetics of human longevity is largely unexplored in Latin American populations and other developing countries. METHODS: To explore the possibility of an association of common polymorphisms in two candidate genes and longevity in Colombia, we analyzed two polymorphisms in apolipoprotein E (APOE) and angiotensin-converting enzyme (ACE) genes in a sample of 538 Colombian subjects (18-106 years), using previously validated PCR-based methodologies. RESULTS: We found a significant decrease in ACE DD genotype (24 vs. 16%) between young and old subject groups (mean age: 45 vs. 77 years) (p = 0.03). The ACE DD genotype and D allele decrease was significant only in women. There were no differences for APOE polymorphism between young and old subjects. CONCLUSIONS: Our results are compatible with the expected age-related decrease of ACE DD genotype. Future studies examining functional single nucleotide polymorphisms (SNPs) in the ACE gene and its correlation with serum ACE activity in the older subjects and their younger relatives in this sample are warranted.
Authors: Bruno A Benitez; Diego A Forero; Gonzalo H Arboleda; Luis A Granados; Juan J Yunis; William Fernandez; Humberto Arboleda Journal: J Genet Date: 2010-08 Impact factor: 1.166
Authors: Silvia Rios-Romenets; Francisco Lopera; Kaycee M Sink; Nan Hu; Qinshu Lian; Heather Guthrie; Jillian Smith; William Cho; Howard Mackey; Jessica B Langbaum; Ronald G Thomas; Margarita Giraldo-Chica; Carlos Tobon; Natalia Acosta-Baena; Claudia Muñoz; Paula Ospina; Victoria Tirado; Eliana Henao; Yamile Bocanegra; Kewei Chen; Yi Su; Dhruman Goradia; Pradeep Thiyyagura; Paul S VanGilder; Ji Luo; Valentina Ghisays; Wendy Lee; Michael H Malek-Ahmadi; Hillary D Protas; Yinghua Chen; Yakeel T Quiroz; Eric M Reiman; Pierre N Tariot Journal: Alzheimers Dement Date: 2020-05-17 Impact factor: 21.566