Literature DB >> 16971205

Bowel perforation from bevacizumab for the treatment of metastatic colon cancer: incidence, etiology, and management.

John H Heinzerling1, Sergio Huerta.   

Abstract

Avastin (Bevacizumab) is a recently developed monoclonal antibody against vascular endothelial growth factor (VEGF) receptor that increases survival in patients with metastatic colorectal cancer. Bowel perforation is a known risk factor of unknown etiology associated with the use of Avastin. In this report, the incidence, risk factors, typical presentation, and management of patients with this complication is described.

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Year:  2006        PMID: 16971205     DOI: 10.1016/j.cursur.2006.06.002

Source DB:  PubMed          Journal:  Curr Surg        ISSN: 0149-7944


  20 in total

1.  Phase II and coagulation cascade biomarker study of bevacizumab with or without docetaxel in patients with previously treated metastatic pancreatic adenocarcinoma.

Authors:  Igor A Astsaturov; Neal J Meropol; R Katherine Alpaugh; Barbara A Burtness; Jonathan D Cheng; Sue McLaughlin; André Rogatko; Zhiheng Xu; James C Watson; Louis M Weiner; Steven J Cohen
Journal:  Am J Clin Oncol       Date:  2011-02       Impact factor: 2.339

Review 2.  Roles for VEGF in the adult.

Authors:  Arindel S R Maharaj; Patricia A D'Amore
Journal:  Microvasc Res       Date:  2007-04-06       Impact factor: 3.514

3.  Enterocutaneous fistula associated with malignancy and prior radiation therapy.

Authors:  Luiz Felipe de Campos-Lobato; Jon D Vogel
Journal:  Clin Colon Rectal Surg       Date:  2010-09

4.  Adalimumab therapy--a double-edged sword?

Authors:  Donal Peter O'Leary; Eddie Myers; Sarah Moran; Tara-Jane Browne; Sinead Harney; William O Kirwan
Journal:  Int J Colorectal Dis       Date:  2011-01-11       Impact factor: 2.571

5.  Risk factors for GI adverse events in a phase III randomized trial of bevacizumab in first-line therapy of advanced ovarian cancer: A Gynecologic Oncology Group Study.

Authors:  Robert A Burger; Mark F Brady; Michael A Bookman; Bradley J Monk; Joan L Walker; Howard D Homesley; Jeffrey Fowler; Benjamin E Greer; Matthew Boente; Gini F Fleming; Peter C Lim; Stephen C Rubin; Noriyuki Katsumata; Sharon X Liang
Journal:  J Clin Oncol       Date:  2014-03-17       Impact factor: 44.544

Review 6.  Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis.

Authors:  Kenji Kawada; Yoshiharu Sakai
Journal:  World J Gastroenterol       Date:  2016-07-07       Impact factor: 5.742

7.  Clinical predictors of bevacizumab-associated intestinal perforation in non-small cell lung cancer.

Authors:  Motohiro Tamiya; Hidekazu Suzuki; Takayuki Shiroyama; Ayako Tanaka; Naoko Morishita; Norio Okamoto; Kenichi Sakai; Hironori Shigeoka; Kunimitsu Kawahara; Tomonori Hirashima
Journal:  Invest New Drugs       Date:  2018-03-14       Impact factor: 3.850

8.  Avastin exhibits therapeutic effects on collagen-induced arthritis in rat model.

Authors:  Yong Wang; Gula Da; Hongbin Li; Yi Zheng
Journal:  Inflammation       Date:  2013-12       Impact factor: 4.092

Review 9.  Late anastomotic breakdown with bevacizumab in colorectal cancers, a case-based review.

Authors:  T O'Hare; R McDermott; R Hannon
Journal:  Ir J Med Sci       Date:  2017-08-29       Impact factor: 1.568

Review 10.  Cardiovascular toxicities: clues to optimal administration of vascular endothelial growth factor signaling pathway inhibitors.

Authors:  Kelly L Snider; Michael L Maitland
Journal:  Target Oncol       Date:  2009-04-17       Impact factor: 4.493

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