Literature DB >> 1696731

Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2--Hox-3.1 intergenic region.

A Awgulewitsch1, C Bieberich, L Bogarad, C Shashikant, F H Ruddle.   

Abstract

The mouse Hox gene family is a set of mammalian homeobox genes that may represent developmental control genes. Complete information about the primary structure of these genes is a prerequisite for a systematic analysis of the mechanisms that determine their complex tempero-spatial expression patterns. In this report we describe the complete sequence of the Hox-3.1 locus and provide evidence for several closely spaced transcriptional start sites. Sequence analysis of the 5' region of the Hox-3.1 gene extending to its nearest upstream neighbor, Hox-3.2, allowed us to identify sequences known to be capable of interactions with transcription factors. Several of these sequence motifs are similar to cis-regulatory elements found in the regulatory regions of other known developmentally regulated genes.

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Year:  1990        PMID： 1696731      PMCID： PMC54547          DOI： 10.1073/pnas.87.16.6428

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  45 in total

Review 1.  Mammalian homeobox-containing genes: genome organization, structure, expression and evolution.

Authors:  K Schughart; C Kappen; F H Ruddle
Journal:  Br J Cancer Suppl       Date:  1988-12

2.  The sequence specificity of homeodomain-DNA interaction.

Authors:  C Desplan; J Theis; P H O'Farrell
Journal:  Cell       Date:  1988-09-23       Impact factor: 41.582

3.  Modulation of epidermal growth factor receptor proto-oncogene transcription by a promoter site sensitive to S1 nuclease.

Authors:  A C Johnson; Y Jinno; G T Merlino
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

4.  Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

Authors:  M A Frohman; M K Dush; G R Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

Review 5.  Homeo boxes in the study of development.

Authors:  W J Gehring
Journal:  Science       Date:  1987-06-05       Impact factor: 47.728

6.  Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.

Authors:  A Awgulewitsch; M F Utset; C P Hart; W McGinnis; F H Ruddle
Journal:  Nature       Date:  1986 Mar 27-Apr 2       Impact factor: 49.962

7.  The murine and Drosophila homeobox gene complexes have common features of organization and expression.

Authors:  A Graham; N Papalopulu; R Krumlauf
Journal:  Cell       Date:  1989-05-05       Impact factor: 41.582

8.  Polypurine/polypyrimidine sequence elements of the murine homeo box loci, Hox-1, -2 and -3.

Authors:  C P Hart; L D Bogarad; A Fainsod; F H Ruddle
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971

9.  Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts.

Authors:  M D Biggin; R Tjian
Journal:  Cell       Date:  1988-06-03       Impact factor: 41.582

10.  Sequential expression of murine homeo box genes during F9 EC cell differentiation.

Authors:  G Breier; M Bućan; U Francke; A M Colberg-Poley; P Gruss
Journal:  EMBO J       Date:  1986-09       Impact factor: 11.598
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  11 in total

1.  Repression of the beta-amyloid gene in a Hox-3.1-producing cell line.

Authors:  S M Violette; C S Shashikant; J M Salbaum; H G Belting; J C Wang; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

2.  Evidence for positive and negative regulation of the Hox-3.1 gene.

Authors:  C J Bieberich; M F Utset; A Awgulewitsch; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

Review 3.  An analysis of vertebrate mRNA sequences: intimations of translational control.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1991-11       Impact factor: 10.539

4.  Combinations of closely situated cis-acting elements determine tissue-specific patterns and anterior extent of early Hoxc8 expression.

Authors:  C S Shashikant; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

5.  Multiple positive and negative regulatory elements in the promoter of the mouse homeobox gene Hoxb-4.

Authors:  A Gutman; J Gilthorpe; P W Rigby
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

6.  Cloning of rat homeobox genes.

Authors:  Y Sakoyama; I Mizuta; N Ogasawara; H Yoshikawa
Journal:  Biochem Genet       Date:  1994-10       Impact factor: 1.890

7.  Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1).

Authors:  I Bach; M Pontoglio; M Yaniv
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

8.  Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8.

Authors:  Hyun Joo Chung; Ji-Yeon Lee; Custer C Deocaris; Hyehyun Min; Sang Hoon Kim; Myoung Hee Kim
Journal:  J Biomed Biotechnol       Date:  2010-05-25

9.  Generation of conditional Hoxc8 loss-of-function and Hoxc8-->Hoxc9 replacement alleles in mice.

Authors:  Jessica Blackburn; Melissa Rich; Nima Ghitani; Jeh-Ping Liu
Journal:  Genesis       Date:  2009-10       Impact factor: 2.487

10.  Activation of the cytotactin promoter by the homeobox-containing gene Evx-1.

Authors:  F S Jones; G Chalepakis; P Gruss; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205
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