Literature DB >> 16967196

An easy access to 2-Amino-5,6-dihydro-3H-pyrimidin-4-one building blocks: the reaction under conventional and microwave conditions.

Konstantin S Ostras1, Nikolay Yu Gorobets, Sergey M Desenko, Vladimir I Musatov.   

Abstract

A new one-stage fast multicomponent synthesis of title compounds leads to products in 21-55% isolated yields under both conventional and microwave conditions. The primary amino group in the building blocks can be easily acylated by various usual electophilic agents that can be utilized in the synthesis of diverse heterocylic compounds libraries.

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Year:  2006        PMID: 16967196     DOI: 10.1007/s11030-006-9045-1

Source DB:  PubMed          Journal:  Mol Divers        ISSN: 1381-1991            Impact factor:   2.943


  5 in total

1.  Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4-dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage.

Authors:  C O Kappe
Journal:  Bioorg Med Chem Lett       Date:  2000-01-03       Impact factor: 2.823

2.  Solid-phase synthesis of 3,4-dihydro-1H-pyrimidine-2-ones using sodium benzenesulfinate as a traceless linker.

Authors:  Weiwei Li; Yulin Lam
Journal:  J Comb Chem       Date:  2005 Sep-Oct

Review 3.  The impact of microwave synthesis on drug discovery.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Nat Rev Drug Discov       Date:  2006-01       Impact factor: 84.694

Review 4.  Biologically active dihydropyrimidones of the Biginelli-type--a literature survey.

Authors:  C O Kappe
Journal:  Eur J Med Chem       Date:  2000-12       Impact factor: 6.514

5.  Microwave-assisted scavenging of electrophiles utilizing polymer-supported sequestration reagents. Application to the synthesis of N3-acylated dihydropyrimidine libraries.

Authors:  Doris Dallinger; Nikolay Yu Gorobets; C Oliver Kappe
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

  5 in total
  4 in total

Review 1.  One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.

Authors:  Victoria V Lipson; Nikolay Yu Gorobets
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

Review 2.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

Review 3.  Synthesis and bioactivity of secondary metabolites from marine sponges containing dibrominated indolic systems.

Authors:  Adriano Mollica; Marcello Locatelli; Azzurra Stefanucci; Francesco Pinnen
Journal:  Molecules       Date:  2012-05-21       Impact factor: 4.411

Review 4.  Microwave multicomponent synthesis.

Authors:  Helmut M Hügel
Journal:  Molecules       Date:  2009-12-01       Impact factor: 4.411

  4 in total

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