Literature DB >> 16964764

Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model.

Yong-Wook Shin1, Eun-Ah Bae, Dong-Hyun Kim.   

Abstract

The effect of a main constituent ginsenoside Rg5 isolated from red ginseng and its metabolite ginsenoside Rh3 in a chronic dermatitis model was investigated. Ginsenosides Rg5 and Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis. These ginsenosides also reduced mRNA expressions of cyclooxygenase-2, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. The inhibition of ginsenoside Rh3 was more potent than that of ginsenoside Rg5. These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of IL-1beta and TNF-alpha produced by macrophage cells and of IFN-gamma produced by Th cells.

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Year:  2006        PMID： 16964764     DOI： 10.1007/bf02968253

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  21 in total

1.  Chemical and pharmacological studies of saponins with a focus on American ginseng.

Authors:  Chun-Su Yuan; Chong-Zhi Wang; Sheila M Wicks; Lian-Wen Qi
Journal:  J Ginseng Res       Date:  2010-09-01       Impact factor: 6.060

Review 2.  Metabolism of ginseng and its interactions with drugs.

Authors:  Lian-Wen Qi; Chong-Zhi Wang; Guang-Jian Du; Zhi-Yu Zhang; Tyler Calway; Chun-Su Yuan
Journal:  Curr Drug Metab       Date:  2011-11       Impact factor: 3.731

3.  Ginsenoside Rg5:Rk1 attenuates TNF-α/IFN-γ-induced production of thymus- and activation-regulated chemokine (TARC/CCL17) and LPS-induced NO production via downregulation of NF-κB/p38 MAPK/STAT1 signaling in human keratinocytes and macrophages.

Authors:  Sungeun Ahn; Muhammad Hanif Siddiqi; Veronica Castro Aceituno; Shakina Yesmin Simu; Jinglou Zhang; Zuly Elizabeth Jimenez Perez; Yu-Jin Kim; Deok-Chun Yang
Journal:  In Vitro Cell Dev Biol Anim       Date:  2015-12-29       Impact factor: 2.416

Review 4.  Chinese medicines reported to have effects on contact dermatitis in the last 20 years.

Authors:  Youngchul Jung; Byungju Kim; Mi Heon Ryu; Hyungwoo Kim
Journal:  Chin J Integr Med       Date:  2017-03-02       Impact factor: 1.978

Review 5.  Ginsenosides from American ginseng: chemical and pharmacological diversity.

Authors:  Lian-Wen Qi; Chong-Zhi Wang; Chun-Su Yuan
Journal:  Phytochemistry       Date:  2011-03-09       Impact factor: 4.072

6.  The role of Dicer protein partners in the processing of microRNA precursors.

Authors:  Edyta Koscianska; Julia Starega-Roslan; Wlodzimierz J Krzyzosiak
Journal:  PLoS One       Date:  2011-12-06       Impact factor: 3.240

7.  Red ginseng extract blocks histamine-dependent itch by inhibition of H1R/TRPV1 pathway in sensory neurons.

Authors:  Yongwoo Jang; Wook-Joo Lee; Gyu-Sang Hong; Won-Sik Shim
Journal:  J Ginseng Res       Date:  2015-01-22       Impact factor: 6.060

Review 8.  Pharmacological activities of ginsenoside Rg5 (Review).

Authors:  Ming-Yang Liu; Fei Liu; Yan-Li Gao; Jia-Ning Yin; Wei-Qun Yan; Jian-Guo Liu; Hai-Jun Li
Journal:  Exp Ther Med       Date:  2021-06-06       Impact factor: 2.447

9.  Protective Effect of Heat-processed Ginseng (Sun Ginseng) in the Adenine-induced Renal Failure Rats.

Authors:  Hyuck Jae Choi; Eun Jin Kim; Yong Wook Shin; Jeong Hill Park; Dong-Hyun Kim; Nam Jae Kim
Journal:  J Ginseng Res       Date:  2012-07       Impact factor: 6.060

10.  Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells.

Authors:  Yu Young Lee; Jin-Sun Park; Ji-Sun Jung; Dong-Hyun Kim; Hee-Sun Kim
Journal:  Int J Mol Sci       Date:  2013-05-08       Impact factor: 5.923
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