Literature DB >> 16964579

Brucella as a biological weapon.

G Pappas1, P Panagopoulou, L Christou, N Akritidis.   

Abstract

Brucella has traditionally been considered a biological weapon. It was the subject of extensive offensive research in the past, and still belongs to category B pathogens on most lists. Its propensity for airborne transmission and induction of chronic debilitating disease requiring combined antibiotic regimens for treatment, its abundance around the world and its vague clinical characteristics defying rapid clinical diagnosis are some of the characteristics that apply to the pathogen's weapons potential. Yet minimal mortality, availability of treatment options, protracted inoculation period and the emergence of new, more virulent potential weapons means that its inclusion among agents of bioterrorism is nowadays mainly of historical significance. Nevertheless, in the interest of literacy and of avoiding panic, physicians and the public both should be aware of the most common zoonosis worldwide.

Mesh:

Year:  2006        PMID: 16964579     DOI: 10.1007/s00018-006-6311-4

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN: 1420-682X            Impact factor:   9.261


  75 in total

1.  Raman spectroscopy as a potential tool for detection of Brucella spp. in milk.

Authors:  Susann Meisel; Stephan Stöckel; Mandy Elschner; Falk Melzer; Petra Rösch; Jürgen Popp
Journal:  Appl Environ Microbiol       Date:  2012-06-01       Impact factor: 4.792

2.  Pathophysiology of the rhesus macaque model for inhalational brucellosis.

Authors:  Lisa N Henning; Stephen M Miller; Dennis H Pak; Amber Lindsay; David A Fisher; Roy E Barnewall; Crystal M Briscoe; Michael S Anderson; Richard L Warren
Journal:  Infect Immun       Date:  2011-11-07       Impact factor: 3.441

3.  Treatment of brucellosis.

Authors:  Georgios Pappas
Journal:  BMJ       Date:  2008-03-05

Review 4.  Review of brucellosis cases from laboratory exposures in the United States in 2008 to 2011 and improved strategies for disease prevention.

Authors:  R M Traxler; M A Guerra; M G Morrow; T Haupt; J Morrison; J R Saah; C G Smith; C Williams; A T Fleischauer; P A Lee; D Stanek; I Trevino-Garrison; P Franklin; P Oakes; S Hand; S V Shadomy; D D Blaney; M W Lehman; T J Benoit; R A Stoddard; R V Tiller; B K De; W Bower; T L Smith
Journal:  J Clin Microbiol       Date:  2013-07-03       Impact factor: 5.948

5.  Crystal structure of Brucella abortus deoxyxylulose-5-phosphate reductoisomerase-like (DRL) enzyme involved in isoprenoid biosynthesis.

Authors:  Jordi Pérez-Gil; Bárbara M Calisto; Christoph Behrendt; Thomas Kurz; Ignacio Fita; Manuel Rodríguez-Concepción
Journal:  J Biol Chem       Date:  2012-03-22       Impact factor: 5.157

6.  Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL.

Authors:  Dola Sengupta; Alicia Koblansky; Jennifer Gaines; Tim Brown; A Phillip West; Dekai Zhang; Tak Nishikawa; Sung-Gyoo Park; R Martin Roop; Sankar Ghosh
Journal:  J Immunol       Date:  2009-12-14       Impact factor: 5.422

Review 7.  Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host.

Authors:  R Martin Roop; Jennifer M Gaines; Eric S Anderson; Clayton C Caswell; Daniel W Martin
Journal:  Med Microbiol Immunol       Date:  2009-09-22       Impact factor: 3.402

8.  Discordant Brucella melitensis antigens yield cognate CD8+ T cells in vivo.

Authors:  Marina A Durward; Jerome Harms; Diogo M Magnani; Linda Eskra; Gary A Splitter
Journal:  Infect Immun       Date:  2009-11-02       Impact factor: 3.441

9.  Brucellosis in infant after familial outbreak.

Authors:  Alexandros C Makis; Georgios Pappas; Emmanouel Galanakis; Nikolaos Haliasos; Antigoni Siamopoulou
Journal:  Emerg Infect Dis       Date:  2008-08       Impact factor: 6.883

10.  ATP-Binding Cassette Systems of Brucella.

Authors:  Dominic C Jenner; Elie Dassa; Adrian M Whatmore; Helen S Atkins
Journal:  Comp Funct Genomics       Date:  2010-02-11
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