Structural-functional reorganization of nonapeptidergic neurosecretory hypothalamic nuclei in experimental acute pancreatitis.

Structures of the pancreas and magnocellular (supraoptic and paraventricular) nuclei of the hypothalamus of adult male rats were studied in conditions of acute pancreatitis at the light and electron microscopic levels. Histo-and organotypic changes in the parenchymatous and stromal elements of the pancreas were analyzed simultaneously with cytological assessment of the state of the nonapeptidergic neurosecretory centers of the hypothalamus. Blockade of the release of hypothalamic nonapeptides was found to occur at the level of axovasal complexes, and this aggravated the outcome of destructive and necrobiotic changes in the pathologically altered organ.