Literature DB >> 16962953

FLT3/D835 mutation and inversion of chromosome 16 in leukemic transformation of myelofibrosis.

Milica Colovic1, Vladimir Jurisic, Sonja Pavlovic, Tatjana Terzic, Natasa Colovic.   

Abstract

We present an atypical case of myelofibrosis developing into secondary leukemia FAB subtype M4, with inversion of chromosome 16, FLT3/D835 point mutation and diffuse osteolytic lesions accompanied by elevated TNF-alpha. The simultaneous occurrence of these mutations reflects the progressive association of genetic lesions developing into secondary leukemia with a relatively benign course.

Entities:  

Year:  2006        PMID： 16962953     DOI： 10.1016/j.ejim.2006.02.028

Source DB:  PubMed          Journal:  Eur J Intern Med        ISSN： 0953-6205            Impact factor:   4.487


  2 in total

1.  Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia.

Authors:  Vladimir Jurisić; Sonja Pavlović; Natasa Colović; Vesna Djordjevic; Vera Bunjevacki; Gradimir Janković; Milica Colović
Journal:  J Genet       Date:  2009-08       Impact factor: 1.166

2.  Analysis of Chromosomal Aberrations and FLT3 gene Mutations in Childhood Acute Myelogenous Leukemia Patients.

Authors:  Ender Coşkunpınar; Sema Anak; Leyla Ağaoğlu; Ayşegül Unüvar; Omer Devecioğlu; Gönül Aydoğan; Cetin Timur; Ahmet Faik Oner; Yıldız Yıldırmak; Tiraje Celkan; Inci Yıldız; Nazan Sarper; Uğur Ozbek
Journal:  Turk J Haematol       Date:  2012-10-05       Impact factor: 1.831
  2 in total

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