| Literature DB >> 16962944 |
Vissaria Sakka1, Sotirios Tsiodras, Evangelos J Giamarellos-Bourboulis, Helen Giamarellou.
Abstract
Persistent neutrophilic leukocytosis above 50,000 cells/muL when the cause is other than leukemia defines a leukemoid reaction. The diagnostic work-up consists of the exclusion of chronic myelogenous leukemia (CML) and chronic neutrophilic leukemia (CNL) and the detection of an underlying cause. The major causes of leukemoid reactions are severe infections, intoxications, malignancies, severe hemorrhage, or acute hemolysis. The present article points out the difficulties in the differential diagnosis of a leukemoid reaction and suggests an algorithm for a rational clinical and laboratory evaluation of this problematic entity.Entities:
Year: 2006 PMID: 16962944 DOI: 10.1016/j.ejim.2006.04.004
Source DB: PubMed Journal: Eur J Intern Med ISSN: 0953-6205 Impact factor: 4.487