BACKGROUND: The purpose of this study was to assess the rate of gastric emptying (GE) in cystic fibrosis patients scheduled for lung transplantation. METHODS: Thirty patients (20 males, 10 females, 22.6 +/- 6.4 years) were evaluated by GE scintigraphy before (1.58 +/- 1.11 years) and early after (5.8 +/- 2.6 weeks) heart-lung transplantation (n = 13) or lung transplantation (n = 17). Solid retention rates at 2 hours (RR2) and 3 hours (RR3) and half-emptying times (T50) of solids and liquids obtained before transplantation were compared with those after transplantation. Data were also compared with those obtained from a control group of 53 healthy volunteers. RESULTS: Before surgery, 20 patients (67%) showed a delayed GE (T50 of solids: patients 160.86 +/- 59.21 minutes vs controls 75.43 +/- 15.13 minutes, p < 0.0001), and 4 of them also had a delayed T50 of liquids. After surgery, the T50 of solids was considered unreliable (too much stasis) in 24 patients. Thus, analyses were done on the basis of solid retention rates. Twenty-nine patients (97%) showed very delayed GE compared with controls (p < 0.0001), 20 of whom also had a delayed T50 of liquids. RR2 and RR3 were significantly higher after surgery than before (RR2 = 86 +/- 17% and RR3 = 77 +/- 22% vs 50 +/- 24% and 27 +/- 24% after and before surgery, respectively, p < 0.0001). However, there was no correlation between pre- and post-transplantation scintigraphy results. CONCLUSIONS: Delayed GE of solids was a frequent abnormality in patients with end-stage cystic fibrosis, with a dramatic delay after surgery in almost all patients. These results emphasize the need for early management of such patients by dietary manipulation or prokinetic medications.
BACKGROUND: The purpose of this study was to assess the rate of gastric emptying (GE) in cystic fibrosispatients scheduled for lung transplantation. METHODS: Thirty patients (20 males, 10 females, 22.6 +/- 6.4 years) were evaluated by GE scintigraphy before (1.58 +/- 1.11 years) and early after (5.8 +/- 2.6 weeks) heart-lung transplantation (n = 13) or lung transplantation (n = 17). Solid retention rates at 2 hours (RR2) and 3 hours (RR3) and half-emptying times (T50) of solids and liquids obtained before transplantation were compared with those after transplantation. Data were also compared with those obtained from a control group of 53 healthy volunteers. RESULTS: Before surgery, 20 patients (67%) showed a delayed GE (T50 of solids: patients 160.86 +/- 59.21 minutes vs controls 75.43 +/- 15.13 minutes, p < 0.0001), and 4 of them also had a delayed T50 of liquids. After surgery, the T50 of solids was considered unreliable (too much stasis) in 24 patients. Thus, analyses were done on the basis of solid retention rates. Twenty-nine patients (97%) showed very delayed GE compared with controls (p < 0.0001), 20 of whom also had a delayed T50 of liquids. RR2 and RR3 were significantly higher after surgery than before (RR2 = 86 +/- 17% and RR3 = 77 +/- 22% vs 50 +/- 24% and 27 +/- 24% after and before surgery, respectively, p < 0.0001). However, there was no correlation between pre- and post-transplantation scintigraphy results. CONCLUSIONS: Delayed GE of solids was a frequent abnormality in patients with end-stage cystic fibrosis, with a dramatic delay after surgery in almost all patients. These results emphasize the need for early management of such patients by dietary manipulation or prokinetic medications.
Authors: P Marco Fisichella; Christopher S Davis; Peter W Lundberg; Erin Lowery; Ellen L Burnham; Charles G Alex; Luis Ramirez; Karen Pelletiere; Robert B Love; Paul C Kuo; Elizabeth J Kovacs Journal: Surgery Date: 2011-10 Impact factor: 3.982
Authors: C S Davis; J Gagermeier; D Dilling; C Alex; E Lowery; E J Kovacs; R B Love; P M Fisichella Journal: Clin Transplant Date: 2010-03-19 Impact factor: 2.863
Authors: Yervant Ichkhanian; Joo Ha Hwang; Andrew Ofosu; Andrew A Li; Daniel Szvarca; Peter V Draganov; Dennis Yang; Eva Alsheik; Tobias Zuchelli; Cyrus Piraka; Shruti Mony; Mouen A Khashab Journal: Endosc Int Open Date: 2022-06-10
Authors: W J Gasper; M P Sweet; C Hoopes; L E Leard; M E Kleinhenz; S R Hays; J A Golden; M G Patti Journal: Surg Endosc Date: 2007-08-18 Impact factor: 4.584
Authors: Juan E Corral; Corey W Dye; Maria R Mascarenhas; Jamie S Barkin; Matthias Salathe; Baharak Moshiree Journal: Scientifica (Cairo) Date: 2016-05-30