INTRODUCTION: Psychiatric manifestations have been reported in cases of manganism, and mood disorders are often observed in manganese (Mn) exposed workers. We examined neuropsychiatric symptoms among formerly Mn-exposed workers 14 years after cessation of exposure. MATERIALS AND METHODS: A study was conducted in 1990 among workers from a ferro- and silico-Mn plant and unexposed working men referents from the same region in South-West Quebec. At follow-up in 2004, 77 former Mn-workers and 81 referents agreed to participate and responded to a neuropsychiatric symptom checklist, the Brief Symptom Inventory (BSI); scores were transformed into T-scores based on a normative population. Cumulated exposure indices (CEI) were computed for each former Mn-worker. Linear and logistic regression analyses were used. RESULTS: Mean T-scores were significantly higher among former Mn-workers than referents on scales of Depression and Anxiety. Mean T-scores of psychological distress increased with the CEI tertiles, with significant associations for the scales Somatization, Depression, Anxiety and Hostility. Former Mn-workers in the two highest tertiles of CEI showed a higher risk for T-scores >or=63 for Hostility (OR, 7.5; 95% CI, 1.5-38.9), Depression (OR, 2.6; 95% CI, 1.1-8.4) and Anxiety (OR, 3.0; 95% CI, 1.1-8.4). CONCLUSION: These results suggest that past exposure to Mn may have lasting consequences on neuropsychiatric symptoms.
INTRODUCTION: Psychiatric manifestations have been reported in cases of manganism, and mood disorders are often observed in manganese (Mn) exposed workers. We examined neuropsychiatric symptoms among formerly Mn-exposed workers 14 years after cessation of exposure. MATERIALS AND METHODS: A study was conducted in 1990 among workers from a ferro- and silico-Mn plant and unexposed working men referents from the same region in South-West Quebec. At follow-up in 2004, 77 former Mn-workers and 81 referents agreed to participate and responded to a neuropsychiatric symptom checklist, the Brief Symptom Inventory (BSI); scores were transformed into T-scores based on a normative population. Cumulated exposure indices (CEI) were computed for each former Mn-worker. Linear and logistic regression analyses were used. RESULTS: Mean T-scores were significantly higher among former Mn-workers than referents on scales of Depression and Anxiety. Mean T-scores of psychological distress increased with the CEI tertiles, with significant associations for the scales Somatization, Depression, Anxiety and Hostility. Former Mn-workers in the two highest tertiles of CEI showed a higher risk for T-scores >or=63 for Hostility (OR, 7.5; 95% CI, 1.5-38.9), Depression (OR, 2.6; 95% CI, 1.1-8.4) and Anxiety (OR, 3.0; 95% CI, 1.1-8.4). CONCLUSION: These results suggest that past exposure to Mn may have lasting consequences on neuropsychiatric symptoms.
Authors: Julie A Moreno; Karin M Streifel; Kelly A Sullivan; William H Hanneman; Ronald B Tjalkens Journal: Toxicol Sci Date: 2011-04-21 Impact factor: 4.849
Authors: Marissa G Baker; Christopher D Simpson; Yvonne S Lin; Laura M Shireman; Noah Seixas Journal: Ann Work Expo Health Date: 2017-05-01 Impact factor: 2.179
Authors: Marissa G Baker; Yvonne S Lin; Christopher D Simpson; Laura M Shireman; Susan Searles Nielsen; Brad A Racette; Noah Seixas Journal: J Trace Elem Med Biol Date: 2018-11-03 Impact factor: 3.849
Authors: Pan Chen; Melissa Totten; Ziyan Zhang; Hana Bucinca; Keith Erikson; Abel Santamaría; Aaron B Bowman; Michael Aschner Journal: Expert Rev Neurother Date: 2019-02-21 Impact factor: 4.618
Authors: Dallas M Cowan; Wei Zheng; Yan Zou; Xiujuan Shi; Jian Chen; Frank S Rosenthal; Qiyuan Fan Journal: Neurotoxicology Date: 2009-02-20 Impact factor: 4.294
Authors: Rachel Grashow; Mark W Miller; Ann McKinney; Linda H Nie; David Sparrow; Howard Hu; Marc G Weisskopf Journal: Neurotoxicol Teratol Date: 2013-04-17 Impact factor: 3.763