BACKGROUND: Asthma is a multi-factorial disorder caused by complex interactions between genetic and environmental factors. IFN-gamma and IFN regulatory factor 1 (IRF-1) affect Th1/Th2 cytokine balance, and influence the differentiation of Th2 cells, which influence the development of asthma. OBJECTIVE: This study investigated CA repeats polymorphism of the IFN-gamma gene and GT repeats polymorphism of the IRF-1 gene, which may predispose individuals to asthma pathogenesis. METHODS: In the present study, we used the transmission/disequilibrium test (TDT) to investigate the relationship between asthma and the IFN-gamma and IRF-1 polymorphisms by studying 348 subjects composed of 232 parents and 116 asthmatic children. RESULTS: For global TDT test, IFN-gamma CA repeats and IRF-1 GT repeat polymorphisms showed a significant association with asthma in children (P=0.009 and 0.017, respectively). We demonstrated that 13 CA repeats (138 bp) of IFN-gamma gene and 11 GT repeats (306 bp) of IRF-1 gene are significantly preferentially transmitted to asthmatic children (T/NT=89/61, chi2=8.43, P<0.005 and T/NT=75/49, chi2=8.18, P<0.005, respectively). The offspring will have an increased risk of asthma when their parents transmit IFN-gamma 13 CA repeats (OR=1.83, P=0.009) and IRF1 11 GT repeats (OR=1.88, P=0.007) to them. But we observed that the IFN-gamma and IRF-1 polymorphisms are not associated with IgE concentrations. CONCLUSION: These findings provide strong evidence of which IFN-gamma CA repeat and IRF-1 GT repeat polymorphisms influence the risk of asthma for children in Taiwan.
BACKGROUND:Asthma is a multi-factorial disorder caused by complex interactions between genetic and environmental factors. IFN-gamma and IFN regulatory factor 1 (IRF-1) affect Th1/Th2 cytokine balance, and influence the differentiation of Th2 cells, which influence the development of asthma. OBJECTIVE: This study investigated CA repeats polymorphism of the IFN-gamma gene and GT repeats polymorphism of the IRF-1 gene, which may predispose individuals to asthma pathogenesis. METHODS: In the present study, we used the transmission/disequilibrium test (TDT) to investigate the relationship between asthma and the IFN-gamma and IRF-1 polymorphisms by studying 348 subjects composed of 232 parents and 116 asthmatic children. RESULTS: For global TDT test, IFN-gamma CA repeats and IRF-1 GT repeat polymorphisms showed a significant association with asthma in children (P=0.009 and 0.017, respectively). We demonstrated that 13 CA repeats (138 bp) of IFN-gamma gene and 11 GT repeats (306 bp) of IRF-1 gene are significantly preferentially transmitted to asthmatic children (T/NT=89/61, chi2=8.43, P<0.005 and T/NT=75/49, chi2=8.18, P<0.005, respectively). The offspring will have an increased risk of asthma when their parents transmit IFN-gamma 13 CA repeats (OR=1.83, P=0.009) and IRF1 11 GT repeats (OR=1.88, P=0.007) to them. But we observed that the IFN-gamma and IRF-1 polymorphisms are not associated with IgE concentrations. CONCLUSION: These findings provide strong evidence of which IFN-gamma CA repeat and IRF-1 GT repeat polymorphisms influence the risk of asthma for children in Taiwan.
Authors: Fred D Finkelman; Simon P Hogan; Gurjit K Khurana Hershey; Marc E Rothenberg; Marsha Wills-Karp Journal: J Immunol Date: 2010-02-15 Impact factor: 5.422
Authors: William J Chapin; Divya Lenkala; Yifeng Mai; Yushan Mao; Steven R White; Rong S Huang Journal: Pharmacogenet Genomics Date: 2015-03 Impact factor: 2.089
Authors: Dagan A Loisel; Zheng Tan; Christopher J Tisler; Michael D Evans; Ronald E Gangnon; Daniel J Jackson; James E Gern; Robert F Lemanske; Carole Ober Journal: J Allergy Clin Immunol Date: 2011-07-27 Impact factor: 10.793
Authors: Rachel A Myers; Nicole M Scott; W James Gauderman; Weiliang Qiu; Rasika A Mathias; Isabelle Romieu; Albert M Levin; Maria Pino-Yanes; Penelope E Graves; Albino Barraza Villarreal; Terri H Beaty; Vincent J Carey; Damien C Croteau-Chonka; Blanca del Rio Navarro; Christopher Edlund; Leticia Hernandez-Cadena; Efrain Navarro-Olivos; Badri Padhukasahasram; Muhammad T Salam; Dara G Torgerson; David J Van den Berg; Hita Vora; Eugene R Bleecker; Deborah A Meyers; L Keoki Williams; Fernando D Martinez; Esteban G Burchard; Kathleen C Barnes; Frank D Gilliland; Scott T Weiss; Stephanie J London; Benjamin A Raby; Carole Ober; Dan L Nicolae Journal: Hum Mol Genet Date: 2014-05-13 Impact factor: 6.150
Authors: Unnur S Bjornsdottir; Stephen T Holgate; Padmalatha S Reddy; Andrew A Hill; Charlotte M McKee; Cristina I Csimma; Amy A Weaver; Holly M Legault; Clayton G Small; Renee C Ramsey; Debra K Ellis; Conor M Burke; Philip J Thompson; Peter H Howarth; Andrew J Wardlaw; Phillip G Bardin; David I Bernstein; Louis B Irving; Geoffrey L Chupp; George W Bensch; Gregory W Bensch; Jon E Stahlman; Monroe Karetzky; James W Baker; Rachel L Miller; Brad H Goodman; Donald G Raible; Samuel J Goldman; Douglas K Miller; John L Ryan; Andrew J Dorner; Frederick W Immermann; Margot O'Toole Journal: PLoS One Date: 2011-07-14 Impact factor: 3.240
Authors: Wings T Y Loo; Chang-bin Fan; Lan-jun Bai; Yuan Yue; Yi-ding Dou; Min Wang; Hao Liang; Mary N B Cheung; Louis W C Chow; Jin-le Li; Ye Tian; Liu Qing Journal: J Transl Med Date: 2012-09-19 Impact factor: 5.531