OBJECTIVES: Adenosine deaminase (ADA) is a non-specific marker of the activation of the T cell, which has an important role in the etiology of Behçet's disease (BD). The purpose of this study was to investigate the determination of ADA activity as an index of T-lymphocyte function in BD, which is known to have an T-cell-mediated immune response. MATERIALS AND METHODS: Adenosine deaminase activities in both serum and erythrocytes were measured in 23 untreated patients with BD and in 20 healthy controls. The patients with BD were divided into two groups: active (n = 10) and inactive (n = 13). RESULTS: When compared with the control group, serum ADA activity was high (P < 0.01) and erythrocyte ADA activity was significantly low (P < 0.01) in BD. Serum ADA activity of active BD was higher than that of inactive BD (P < 0.01), but erythrocyte ADA activity was found to be lower in active BD than inactive BD (P < 0.01). COMMENT: These findings may provide an additional benefit for the diagnosis of BD and sub-typing of active and inactive BD.
OBJECTIVES:Adenosine deaminase (ADA) is a non-specific marker of the activation of the T cell, which has an important role in the etiology of Behçet's disease (BD). The purpose of this study was to investigate the determination of ADA activity as an index of T-lymphocyte function in BD, which is known to have an T-cell-mediated immune response. MATERIALS AND METHODS:Adenosine deaminase activities in both serum and erythrocytes were measured in 23 untreated patients with BD and in 20 healthy controls. The patients with BD were divided into two groups: active (n = 10) and inactive (n = 13). RESULTS: When compared with the control group, serum ADA activity was high (P < 0.01) and erythrocyte ADA activity was significantly low (P < 0.01) in BD. Serum ADA activity of active BD was higher than that of inactive BD (P < 0.01), but erythrocyte ADA activity was found to be lower in active BD than inactive BD (P < 0.01). COMMENT: These findings may provide an additional benefit for the diagnosis of BD and sub-typing of active and inactive BD.
Authors: Mahmut Sunnetcioglu; Sevdegul Karadas; Mehmet Aslan; Mehmet Resat Ceylan; Halit Demir; Mehmet Resit Oncu; Mustafa Kasım Karahocagil; Aysel Sunnetcioglu; Cenk Aypak Journal: Med Sci Monit Date: 2014-07-06