Literature DB >> 1696145

Effects of recombinant human granulocyte colony-stimulating factor on the hematologic recovery and survival of irradiated mice.

S Tanikawa1, M Nose, Y Aoki, K Tsuneoka, M Shikita, N Nara.   

Abstract

We studied the effects of intraperitoneal injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) according to various administration schedules on the recovery of spleen colony-forming units (CFU-S) and peripheral blood counts, and on the survival of irradiated mice. The sooner and more frequently the mice were injected with rhG-CSF after irradiation, the more enhanced the recovery of CFU-S in bone marrow was obtained on day 7. Twice-daily injections of rhG-CSF from day 0 to day 2 significantly enhanced the recovery of platelets and hematocrit, but two injections of rhG-CSF on only day 0 did not. Twice-daily injections of rhG-CSF from day 0 to day 6 enhanced the recovery of platelets more effectively than twice-daily injections of rhG-CSF from day 1 to day 7, and increased the survival of irradiated mice more effectively than any other examined administration schedules. Twice-daily injections of rhG-CSF from day 0 to day 6 were significantly effective in enhancing the survival of mice irradiated with 8.5-, 9.0-, and 9.5-Gy x-rays, although not effective after irradiation of 10.5-Gy x-rays.

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Year:  1990        PMID： 1696145

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  16 in total

1.  Effect in supralethally irradiated rats of granulocyte colony-stimulating factor and lisofylline on hematopoietic reconstitution by syngeneic bone marrow or whole organ passenger leukocytes.

Authors:  N Murase; Q Ye; T Sakamoto; M Terakura; A J Demetris; A W Thomson; A Rao; T E Starzl
Journal:  Transplantation       Date:  1997-06-27       Impact factor: 4.939

2.  Impact of Abbreviated Filgrastim Schedule on Survival and Hematopoietic Recovery after Irradiation in Four Mouse Strains with Different Radiosensitivity.

Authors:  Merriline Satyamitra; Vidya P Kumar; Shukla Biswas; Lynnette Cary; Leonora Dickson; Srinivasan Venkataraman; Sanchita P Ghosh
Journal:  Radiat Res       Date:  2017-03-31       Impact factor: 2.841

Review 3.  Recombinant granulocyte colony-stimulating factor (rG-CSF). A review of its pharmacological properties and prospective role in neutropenic conditions.

Authors:  L M Hollingshead; K L Goa
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

4.  Mitigation of ionizing radiation-induced bone marrow suppression by p38 inhibition and G-CSF administration.

Authors:  Deguan Li; Yueying Wang; Hongying Wu; Lu Lu; Heng Zhang; Jianhui Chang; Zhibin Zhai; Junling Zhang; Yong Wang; Daohong Zhou; Aimin Meng
Journal:  J Radiat Res       Date:  2011-10-05       Impact factor: 2.724

5.  Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.

Authors:  Benny J Chen; Divino Deoliveira; Ivan Spasojevic; Gregory D Sempowski; Chen Jiang; Kouros Owzar; Xiaojuan Wang; Diane Gesty-Palmer; J Mark Cline; J Daniel Bourland; Greg Dugan; Sarah K Meadows; Pamela Daher; Garrett Muramoto; John P Chute; Nelson J Chao
Journal:  PLoS One       Date:  2010-06-16       Impact factor: 3.240

6.  Filgrastim improves survival in lethally irradiated nonhuman primates.

Authors:  Ann M Farese; Melanie V Cohen; Barry P Katz; Cassandra P Smith; Allison Gibbs; Daniel M Cohen; Thomas J MacVittie
Journal:  Radiat Res       Date:  2012-12-04       Impact factor: 2.841

7.  Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome.

Authors:  P Artur Plett; Carol H Sampson; Hui Lin Chua; Mandar Joshi; Catherine Booth; Alec Gough; Cynthia S Johnson; Barry P Katz; Ann M Farese; Jeffrey Parker; Thomas J MacVittie; Christie M Orschell
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

8.  The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent.

Authors:  Ann M Farese; Cassandra R Brown; Cassandra P Smith; Allison M Gibbs; Barry P Katz; Cynthia S Johnson; Karl L Prado; Thomas J MacVittie
Journal:  Health Phys       Date:  2014-01       Impact factor: 1.316

9.  An anti-apoptotic peptide improves survival in lethal total body irradiation.

Authors:  Jonathan E McDunn; Jared T Muenzer; Benjamin Dunne; Anthony Zhou; Kevin Yuan; Andrew Hoekzema; Carolyn Hilliard; Katherine C Chang; Christopher G Davis; Jacquelyn McDonough; Clayton Hunt; Perry Grigsby; David Piwnica-Worms; Richard S Hotchkiss
Journal:  Biochem Biophys Res Commun       Date:  2009-03-19       Impact factor: 3.575

10.  Effects of recombinant human granulocyte colony-stimulating factor on central and peripheral T lymphocyte reconstitution after sublethal irradiation in mice.

Authors:  Hongxia Zhao; Mei Guo; Xuedong Sun; Wanjun Sun; Hailan Hu; Li Wei; Huisheng Ai
Journal:  J Radiat Res       Date:  2012-09-20       Impact factor: 2.724
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