Literature DB >> 16961290

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans.

Shenghao Tu1, Hongbo Chen, Dongyun Sheng, Yonghong Hu, Peilin Liu.   

Abstract

The relationship between tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and inhibitory effects of triptolide on TNF-alpha production from peripheral blood mononuclear cells (PBMC) of healthy humans was investigated. Genomic DNA from 41 healthy people was typed for TNF-alpha--308 polymorphism by allele-specific polymorphism chain reaction (AS-PCR). The TNF-alpha concentration in the supernatant was measured by ELISA. The results showed that the production of TNF-alpha from TNF-alpha--308 non-G/G genotype PBMC was higher than that from TNF-alpha--308 G/G genotype PBMC after stimulated by LPS. Triptolide could lower the production of TNF-alpha from G/ G genotype PBMC, but had no effect on the level of TNF-alpha from non-G/G genotype PBMC. It was concluded that TNF-alpha gene polymorphism was related to the TNF-alpha production from triptolide-inhibited PBMC culture in healthy humans.

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Year:  2006        PMID： 16961290     DOI： 10.1007/bf02829572

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  9 in total

1.  Clinical pharmacogenomics: applications in pharmaceutical R&D.

Authors:  R M. Norton
Journal:  Drug Discov Today       Date:  2001-02-01       Impact factor: 7.851

2.  The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription.

Authors:  K M Kroeger; K S Carville; L J Abraham
Journal:  Mol Immunol       Date:  1997-04       Impact factor: 4.407

3.  Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin's lymphoma outcome.

Authors:  K Warzocha; P Ribeiro; J Bienvenu; P Roy; C Charlot; D Rigal; B Coiffier; G Salles
Journal:  Blood       Date:  1998-05-15       Impact factor: 22.113

4.  Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.

Authors:  E Louis; D Franchimont; A Piron; Y Gevaert; N Schaaf-Lafontaine; S Roland; P Mahieu; M Malaise; D De Groote; R Louis; J Belaiche
Journal:  Clin Exp Immunol       Date:  1998-09       Impact factor: 4.330

5.  The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases.

Authors:  C Cipriano; C Caruso; D Lio; R Giacconi; M Malavolta; E Muti; N Gasparini; C Franceschi; E Mocchegiani
Journal:  Int J Immunogenet       Date:  2005-02       Impact factor: 1.466

6.  Tumor necrosis factor promoter polymorphisms in patients with rheumatoid arthritis in Taiwan.

Authors:  J H Yen; C J Chen; W C Tsai; C H Lin; T T Ou; C C Wu; H W Liu
Journal:  J Rheumatol       Date:  2001-08       Impact factor: 4.666

7.  Investigation of the prognostic value of TNF-alpha gene polymorphism among patients treated with infliximab, and the effects of infliximab therapy on TNF-alpha production and apoptosis.

Authors:  Attila Balog; Gergely Klausz; János Gál; Tamás Molnár; Ferenc Nagy; Imre Ocsovszky; Zsófia Gyulai; Yvette Mándi
Journal:  Pathobiology       Date:  2004       Impact factor: 4.342

8.  Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis.

Authors:  L Padyukov; J Lampa; M Heimbürger; S Ernestam; T Cederholm; I Lundkvist; P Andersson; Y Hermansson; A Harju; L Klareskog; J Bratt
Journal:  Ann Rheum Dis       Date:  2003-06       Impact factor: 19.103

9.  Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation.

Authors:  A G Wilson; J A Symons; T L McDowell; H O McDevitt; G W Duff
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205
  9 in total

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