Literature DB >> 1696018

Regional distribution of neuropeptide gamma and other tachykinin peptides derived from the substance P gene in the rat.

Y Takeda1, J Takeda, B M Smart, J E Krause.   

Abstract

Substance P (SP) and multiple neurokinin A (NKA)-related peptides can be derived from alpha-, beta- and/or gamma-preprotachykinin (PPT) mRNAs. In this study, the relative concentrations of the tachykinin peptides derived from the SP gene in rat brain, duodenum, jejunum, submandibular gland, parotid gland, urinary bladder and vas deferens was determined using high-performance liquid chromatography (HPLC) and radioimmunoassays (RIAs). In all tissues, SP levels were the highest. The relative abundance of NKA-related peptides was NKA greater than neuropeptide gamma (NP gamma) = neuropeptide K (NPK) greater than NKA(3-10). These results demonstrate that multiple tachykinin peptides are present in tissues where the SP gene is expressed, and that the NKA portion of the beta- and gamma-PPT precursors can be differentially processed posttranslationally in rat tissues into NKA, NPK, NP gamma and/or NKA(3-10).

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Year:  1990        PMID： 1696018     DOI： 10.1016/0167-0115(90)90030-z

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  9 in total

1.  Tachykinin receptors mediate atropine-resistant rat duodenal reflex contractions in vivo.

Authors:  S Giuliani; M Tramontana; A Lecci; C A Maggi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996 Aug-Sep       Impact factor: 3.000

2.  Intracerebroventricular responses to neuropeptide gamma in the conscious rat: characterization of its receptor with selective antagonists.

Authors:  P Picard; R Couture
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

3.  Cardiovascular responses to intrathecal neuropeptide gamma in conscious rats: receptor characterization and mechanism of action.

Authors:  P Poulat; J de Champlain; R Couture
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

Review 4.  Probing neuropeptide signaling at the organ and cellular domains via imaging mass spectrometry.

Authors:  Hui Ye; Tyler Greer; Lingjun Li
Journal:  J Proteomics       Date:  2012-03-20       Impact factor: 4.044

5.  Tachykinin antagonists and capsaicin-induced contraction of the rat isolated urinary bladder: evidence for tachykinin-mediated cotransmission.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

6.  Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract.

Authors:  E F Grady; P Baluk; S Böhm; P D Gamp; H Wong; D G Payan; J Ansel; A L Portbury; J B Furness; D M McDonald; N W Bunnett
Journal:  J Neurosci       Date:  1996-11-01       Impact factor: 6.167

7.  Primary structure and receptor-binding properties of a neurokinin A-related peptide from frog gut.

Authors:  Y Wang; T Badgery-Parker; S Lovas; N Chartrel; H Vaudry; E Burcher; J M Conlon
Journal:  Biochem J       Date:  1992-11-01       Impact factor: 3.857

8.  Human neuronal cells (NT2-N) express functional substance P and neurokinin-1 receptor coupled to MIP-1 beta expression.

Authors:  Yuan Li; Steven D Douglas; David E Pleasure; Jianping Lai; Changjiang Guo; Peter Bannerman; Marge Williams; Wenzhe Ho
Journal:  J Neurosci Res       Date:  2003-02-15       Impact factor: 4.164

9.  Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences.

Authors:  M G Belvisi; R Patacchini; P J Barnes; C A Maggi
Journal:  Br J Pharmacol       Date:  1994-01       Impact factor: 8.739
  9 in total

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