Literature DB >> 16959558

Targeting protein stability with a small molecule.

Michael A Lampson1, Tarun M Kapoor.   

Abstract

Both genetic approaches and small-molecule inhibitors can be used to perturb protein function. Banaszynski et al. (2006) now describe a strategy to regulate the stability of a target protein, in which specificity is provided by a genetically encoded tag and temporal control is imparted by a small molecule.

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Year:  2006        PMID： 16959558     DOI： 10.1016/j.cell.2006.08.023

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  4 in total

1.  Peptidic degron for IMiD-induced degradation of heterologous proteins.

Authors:  Vidyasagar Koduri; Samuel K McBrayer; Ella Liberzon; Adam C Wang; Kimberly J Briggs; Hyejin Cho; William G Kaelin
Journal:  Proc Natl Acad Sci U S A       Date:  2019-01-25       Impact factor: 11.205

Review 2.  The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics.

Authors:  Kabirul Islam
Journal:  Cell Chem Biol       Date:  2018-08-02       Impact factor: 8.116

3.  An IMiD-induced SALL4 degron system for selective degradation of target proteins.

Authors:  Satoshi Yamanaka; Yuki Shoya; Saya Matsuoka; Hisayo Nishida-Fukuda; Norio Shibata; Tatsuya Sawasaki
Journal:  Commun Biol       Date:  2020-09-18

4.  Tunable and reversible drug control of protein production via a self-excising degron.

Authors:  Hokyung K Chung; Conor L Jacobs; Yunwen Huo; Jin Yang; Stefanie A Krumm; Richard K Plemper; Roger Y Tsien; Michael Z Lin
Journal:  Nat Chem Biol       Date:  2015-07-27       Impact factor: 15.040
  4 in total

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