Literature DB >> 16959487

Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators.

Xuqing Zhang1, George F Allan, Tifanie Sbriscia, Olivia Linton, Scott G Lundeen, Zhihua Sui.   

Abstract

A novel series of hydantoin derivatives were identified by in vivo studies as tissue selective androgen receptor modulators. SAR around this series revealed that the function of the ligand could be altered by minor structural modification.

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Year:  2006        PMID： 16959487     DOI： 10.1016/j.bmcl.2006.08.084

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones.

Authors:  Robert I Higuchi; Anthony W Thompson; Jyun-Hung Chen; Thomas R Caferro; Marquis L Cummings; Charlotte P Deckhut; Mark E Adams; Christopher M Tegley; James P Edwards; Francisco J López; E Adam Kallel; Donald S Karanewsky; William T Schrader; Keith B Marschke; Lin Zhi
Journal:  Bioorg Med Chem Lett       Date:  2007-07-25       Impact factor: 2.823

2.  A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats.

Authors:  George F Allan; Pamela Tannenbaum; Tifanie Sbriscia; Olivia Linton; Muh-Tsann Lai; Donna Haynes-Johnson; Sheela Bhattacharjee; Xuqing Zhang; Zhihua Sui; Scott G Lundeen
Journal:  Endocrine       Date:  2007-10-02       Impact factor: 3.633

3.  Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978).

Authors:  Chunkai Wang; Qingjie Zhao; Mireille Vargas; Jeremy O Jones; Karen L White; David M Shackleford; Gong Chen; Jessica Saunders; Alice C F Ng; Francis C K Chiu; Yuxiang Dong; Susan A Charman; Jennifer Keiser; Jonathan L Vennerstrom
Journal:  J Med Chem       Date:  2016-11-28       Impact factor: 7.446

Review 4.  Selective androgen receptor modulators in preclinical and clinical development.

Authors:  Ramesh Narayanan; Michael L Mohler; Casey E Bohl; Duane D Miller; James T Dalton
Journal:  Nucl Recept Signal       Date:  2008-11-26
  4 in total

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