Literature DB >> 16959457

Why aging isn't regulated: a lamentation on the use of language in aging literature.

Gordon J Lithgow1.   

Abstract

Aging research has a problem. The field is expanding rapidly but our understanding of aging is clouded because of the language we use when describing genes that influence aging. As researchers from different disciplines gather to solve aging problems, different terms are being used to describe genetic affects. Genetic alterations can bring about enormous changes in lifespan but the significance of these experiments is debated; either the results are hailed as spectacular breakthroughs or alternatively considered laboratory artifacts unlikely to reveal useful knowledge about aging. How could this have come about and what do we need to do about it? I suggest we need to listen to exactly what each other is saying and also think carefully about how we are using key terms when describing our results. Rather than a scholarly review of this important issue, this article is intended to prompt debate. Consequently, "the gloves are off".

Mesh:

Year:  2006        PMID: 16959457     DOI: 10.1016/j.exger.2006.06.051

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN: 0531-5565            Impact factor:   4.032


  8 in total

Review 1.  Detoxification reactions: relevance to aging.

Authors:  Piotr Zimniak
Journal:  Ageing Res Rev       Date:  2008-05-02       Impact factor: 10.895

Review 2.  Relationship of electrophilic stress to aging.

Authors:  Piotr Zimniak
Journal:  Free Radic Biol Med       Date:  2011-06-12       Impact factor: 7.376

3.  Age-dependent expression profiles of two adaptogenic systems and thermotolerance in Drosophila melanogaster.

Authors:  V Shilova; O Zatsepina; A Zakluta; D Karpov; L Chuvakova; D Garbuz; M Evgen'ev
Journal:  Cell Stress Chaperones       Date:  2020-02-10       Impact factor: 3.667

Review 4.  Stress proteins in aging and life span.

Authors:  Ayesha Murshid; Takanori Eguchi; Stuart K Calderwood
Journal:  Int J Hyperthermia       Date:  2013-06-06       Impact factor: 3.914

Review 5.  Hsps and aging.

Authors:  John Tower
Journal:  Trends Endocrinol Metab       Date:  2009-04-24       Impact factor: 12.015

Review 6.  Caenorhabditis elegans 2007: the premier model for the study of aging.

Authors:  Thomas E Johnson
Journal:  Exp Gerontol       Date:  2007-10-01       Impact factor: 4.032

Review 7.  Aging and longevity: why knowing the difference is important to nutrition research.

Authors:  Roger B McDonald; Rodney C Ruhe
Journal:  Nutrients       Date:  2011-02-28       Impact factor: 5.717

8.  Using C. elegans for aging research.

Authors:  Heidi A Tissenbaum
Journal:  Invertebr Reprod Dev       Date:  2014-12-09       Impact factor: 0.952

  8 in total

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