| Literature DB >> 16959224 |
Soon-Tae Lee1, Kon Chu, Jung-Eun Park, Lami Kang, Song-Yi Ko, Keun-Hwa Jung, Manho Kim.
Abstract
Huntington's disease has an increase in the activated calpain, which is enhanced by the NMDA receptor activation. We investigated the neuroprotective effect of memantine in 3-nitropropionic acid (3NP)-induced striatal degeneration model. Either memantine (20 mg/kg/day) or PBS was intraperitoneally administered for five days with 3NP continuous infusion. In the memantine-treated group, the striatal lesion volume, the number of TUNEL+ cells, and Fluoro-Jade C+ degenerating neurons were all decreased. Memantine increased Bcl-xl and decreased Bax level. Memantine also exerted an inhibitory effect on the micro-calpain level and decreased the huntingtin proteolytic fragments. Those rats treated with memantine showed less degree of weight loss at 5 days. Subsequently, memantine was found to have neuroprotective effects and save striatal cells with decreasing calpain levels in the 3NP model of Huntington's disease.Entities:
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Year: 2006 PMID： 16959224 DOI： 10.1016/j.brainres.2006.08.035
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252