Karen A Thomas1, Robert L Burr. 1. Department of Family and Child Nursing in the University of Washington, Seattle, USA. kthomas@u.washington.edu
Abstract
OBJECTIVE: To compare 24-hour melatonin level and timing in postpartum and nonpregnant nulliparous women. Melatonin release provides information regarding circadian rhythm timing, which influences health. DESIGN: 2-group comparison of data derived from intensive within-subject data collection. SETTING: Participants' typical daily environment. PARTICIPANTS: 38 postpartum and 20 nonpregnant nulliparous women. Mothers' infants were 4 to 10 weeks of postnatal age. MAIN OUTCOME MEASURES: Urinary 6-sulfatoxymelatonin assayed from each voiding and corrected for volume using creatinine. RESULTS: Postpartum women had significantly higher baseline, lower maximum, lower percent rise, and differing pattern of 6-sulfatoxymelatonin than nonpregnant nulliparous women. CONCLUSION: Differences in melatonin suggest possible circadian rhythm disruption in the postnatal period. (c) 2006, AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses
OBJECTIVE: To compare 24-hour melatonin level and timing in postpartum and nonpregnant nulliparous women. Melatonin release provides information regarding circadian rhythm timing, which influences health. DESIGN: 2-group comparison of data derived from intensive within-subject data collection. SETTING:Participants' typical daily environment. PARTICIPANTS: 38 postpartum and 20 nonpregnant nulliparous women. Mothers' infants were 4 to 10 weeks of postnatal age. MAIN OUTCOME MEASURES: Urinary 6-sulfatoxymelatonin assayed from each voiding and corrected for volume using creatinine. RESULTS: Postpartum women had significantly higher baseline, lower maximum, lower percent rise, and differing pattern of 6-sulfatoxymelatonin than nonpregnant nulliparous women. CONCLUSION: Differences in melatonin suggest possible circadian rhythm disruption in the postnatal period. (c) 2006, AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses
Authors: Henry J Orff; Charles J Meliska; Ana Lopez; Fernando Martinez; Diane Sorenson; Barbara L Parry Journal: Dialogues Clin Neurosci Date: 2012-12 Impact factor: 5.986