Eibhlín M McLoone1, Trevor A S Buchanan. 1. Department of Ophthalmology, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland. eibhlin_mcloone@hotmail.com
Abstract
BACKGROUND: Retinal involvement in neurofibromatosis type-1 (NF-1) is rare. METHODS: We present a case report of a 49-year-old man with neurofibromatosis who developed bilateral macular lesions associated with gradual reduction of visual acuity. RESULTS: Electrophysiology revealed an absent pattern electroretinogram. Fluorescein angiography demonstrated mottled hyperfluorescence of the maculae in the early-phase fluorescein angiogram followed by late staining of the lesions. CONCLUSIONS: Our patient had unusual bilateral macular lesions which had some features suggestive of adult-onset foveomacular vitelliform dystrophy. To the best of our knowledge, there have been no previous reports of such macular lesions occurring in association with NF-1.
BACKGROUND: Retinal involvement in neurofibromatosis type-1 (NF-1) is rare. METHODS: We present a case report of a 49-year-old man with neurofibromatosis who developed bilateral macular lesions associated with gradual reduction of visual acuity. RESULTS: Electrophysiology revealed an absent pattern electroretinogram. Fluorescein angiography demonstrated mottled hyperfluorescence of the maculae in the early-phase fluorescein angiogram followed by late staining of the lesions. CONCLUSIONS: Our patient had unusual bilateral macular lesions which had some features suggestive of adult-onset foveomacular vitelliform dystrophy. To the best of our knowledge, there have been no previous reports of such macular lesions occurring in association with NF-1.
Authors: M Destro; D J D'Amico; E S Gragoudas; R J Brockhurst; M K Pinnolis; D M Albert; T M Topping; C A Puliafito Journal: Arch Ophthalmol Date: 1991-05