Literature DB >> 1695725

Intracellular localization of pp60c-src in human platelets.

J E Ferrell1, J A Noble, G S Martin, Y V Jacques, D F Bainton.   

Abstract

We have studied the intracellular distribution of the proto-oncogene product pp60c-src in human platelets by immunofluorescence microscopy and by immunogold electron microscopy on frozen thin sections. Virtually all of the immunoreactive pp60c-src was found to be associated with the plasma membrane and with membranes of the surface-connected canalicular system. This localization suggests that pp60c-src may relay signals from an as yet unidentified cell surface protein to intracellular targets.

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Year:  1990        PMID： 1695725

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  7 in total

Review 1.  The c-src family of protein-tyrosine kinases.

Authors:  P M Brickell
Journal:  Int J Exp Pathol       Date:  1991-02       Impact factor: 1.925

2.  Tyrosine phosphorylation of P-selectin in intact platelets and in a disulphide-linked complex with immunoprecipitated pp60c-src.

Authors:  P W Modderman; A E von dem Borne; A Sonnenberg
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

3.  Translocation of pp60c-src to the cytoskeleton during platelet aggregation.

Authors:  A R Horvath; L Muszbek; S Kellie
Journal:  EMBO J       Date:  1992-03       Impact factor: 11.598

4.  Substrate recognition by osteoclast precursors induces C-src/microtubule association.

Authors:  Y Abu-Amer; F P Ross; P Schlesinger; M M Tondravi; S L Teitelbaum
Journal:  J Cell Biol       Date:  1997-04-07       Impact factor: 10.539

5.  Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells.

Authors:  T David-Pfeuty; Y Nouvian-Dooghe
Journal:  J Cell Biol       Date:  1990-12       Impact factor: 10.539

6.  Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle.

Authors:  A D Linstedt; M L Vetter; J M Bishop; R B Kelly
Journal:  J Cell Biol       Date:  1992-06       Impact factor: 10.539

7.  Osteoclasts express high levels of pp60c-src in association with intracellular membranes.

Authors:  W C Horne; L Neff; D Chatterjee; A Lomri; J B Levy; R Baron
Journal:  J Cell Biol       Date:  1992-11       Impact factor: 10.539
  7 in total

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