| Literature DB >> 16956589 |
Reiko Kuno1, Yusuke Yoshida, Atsumi Nitta, Toshitaka Nabeshima, Jinyan Wang, Yoshifumi Sonobe, Jun Kawanokuchi, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura.
Abstract
The neurotrophic factors, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), are produced by astrocytes, and are induced by inflammatory stimuli including bacterial lipopolysaccharide and pro-inflammatory cytokines. In this study, we examined the regulatory mechanisms of tumor necrosis factor-alpha (TNF-alpha)-induced production of neurotrophic factors. We show here that cultured astrocytes express both TNF-alpha receptor 1 (TNFR1) and TNFR2, and that activation of these receptors by TNF-alpha promotes expression of both NGF and GDNF. In addition, we observe that not only exogenous TNF-alpha but also TNF-alpha produced by astrocytes induce NGF and GDNF production in astrocytes. These results suggest that an autocrine loop involving TNF-alpha contributes to the production of neurotrophic factors in response to inflammation.Entities:
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Year: 2006 PMID： 16956589 DOI： 10.1016/j.brainres.2006.07.120
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252